Mao Fan, Xu Zhihua, Shao Meihua, Xiang Xuelian, Zhou Xiaoli
Department of Radiology, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Front Neurol. 2024 Aug 29;15:1417805. doi: 10.3389/fneur.2024.1417805. eCollection 2024.
To explore the relationship between the deep medullary vein (DMV) score and atrophy in patients with cerebral small vessel disease (CSVD).
Imaging and clinical data from 125 patients with CSVD from January to December 2022 were reviewed. Normalized gray matter volume (GM_N) was calculated by dividing the gray matter volume by the whole brain volume. DMV scoring is conducted using susceptibility-weighted magnetic resonance imaging, wherein the DMV area is partitioned into six distinct regions: bilateral frontal, parietal, and occipital regions. Each region undergoes assessment based on the clarity and consistency of DMV visibility. Subsequently, the scores from these six regions are summed, resulting in a score ranging from 0 to 18 points.
DMV score was associated with GM_N ( = -0.376, < 0.001). Comparisons among patients according to GM_N tertiles, differences in gender, age, current smoking, DMV score, and total CSVD magnetic resonance imaging score were demonstrated ( < 0.05). Adjusting for age, gender, vascular risk factors, and total CSVD MR score, the DMV score was independently associated with GM_N [ (95% CI): -0.347 (-0.525, -0.168), < 0.001].
DMV scores are independently associated with GM_N, and DMV dysfunction may play a role in brain atrophy.
探讨脑小血管病（CSVD）患者的深髓静脉（DMV）评分与脑萎缩之间的关系。
回顾了2022年1月至12月期间125例CSVD患者的影像学和临床资料。通过将灰质体积除以全脑体积来计算标准化灰质体积（GM_N）。使用磁敏感加权磁共振成像进行DMV评分，其中DMV区域被划分为六个不同区域：双侧额叶、顶叶和枕叶区域。每个区域根据DMV可见性的清晰度和一致性进行评估。随后，将这六个区域的评分相加，得出的分数范围为0至18分。
DMV评分与GM_N相关（= -0.376，< 0.001）。根据GM_N三分位数对患者进行比较，结果显示性别、年龄、当前吸烟情况、DMV评分和CSVD磁共振成像总评分存在差异（< 0.05）。在调整年龄、性别、血管危险因素和CSVD磁共振成像总评分后，DMV评分与GM_N独立相关[（95% CI）：-0.347（-0.525，-0.168），< 0.001]。
DMV评分与GM_N独立相关，DMV功能障碍可能在脑萎缩中起作用。
