A组链球菌产生致热外毒素。
The production of pyrogenic exotoxins by group A streptococci.
作者信息
Hallas G
出版信息
J Hyg (Lond). 1985 Aug;95(1):47-57. doi: 10.1017/s0022172400062276.
Abstract
Lancefield group A streptococci isolated from recent outbreaks and sporadic cases of scarlet fever were restricted to the following M types 1, 3, 4, 6, 12, 18, 22 and 66. These strains were examined for the presence of streptococcal pyrogenic exotoxins (SPE) types A, B and C by isoelectric focusing in polyacrylamide gels and by immunoprecipitation in agar gels. SPE B was produced by 70% of the strains and SPE C by 40%. SPE A could not be detected in these strains. In contrast, SPE type A was found in 4 of 10 strains, held by the NCTC, that had been isolated before 1940 from patients with scarlet fever. Nine of 12 recent isolates from patients with sore throat uncomplicated by a rash produced SPE C and 4 of these also produced SPE B.
摘要
从近期猩红热暴发和散发病例中分离出的A群兰斯菲尔德链球菌局限于以下M型：1、3、4、6、12、18、22和66型。通过聚丙烯酰胺凝胶等电聚焦和琼脂凝胶免疫沉淀法检测这些菌株是否存在A、B和C型链球菌致热外毒素（SPE）。70%的菌株产生SPE B，40%的菌株产生SPE C。在这些菌株中未检测到SPE A。相比之下，在1940年以前从猩红热患者中分离出的、由英国国家典型菌种保藏中心保存的10株菌株中，有4株发现了A 型SPE。12株近期从无皮疹并发症的咽痛患者中分离出的菌株中有9株产生SPE C，其中4株还产生SPE B。
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