免疫检查点抑制剂在老年非小细胞肺癌患者中的毒性与疗效的相关性。
The association between toxicity and efficacy of immune checkpoint inhibitors in older adults with NSCLC.
机构信息
Department of Pharmacy Administration, University of Mississippi, P.O. Box 1848, University, MS 38677, USA.
Associate Professor of Pharmacy Administration, Assistant Director for the Center for Pharmaceutical Marketing & Management, Research Associate Professor in the Research Institute of Pharmaceutical Sciences, University of Mississippi, P.O. Box 1848, University, MS 38677, USA.
出版信息
Immunotherapy. 2024;16(16-17):1057-1068. doi: 10.1080/1750743X.2024.2394382. Epub 2024 Sep 13.
This cohort study evaluated the association between immune checkpoint inhibitors (ICIs)-induced immune-related adverse events (irAEs) and mortality as well as ICI discontinuation among older adults with NSCLC. 2007-2019 Surveillance, Epidemiology and End Results-Medicare linked database was used and survival analysis with time-varying exposure of irAEs was applied to estimate the associations. A total of 8,175 individuals were included, with 46.8% of whom developed an irAE. Cox regression models showed the occurrence of any irAEs was associated with increased risk of mortality (HR: 1.73, 95% CI: 1.63-1.82) and treatment discontinuation (HR: 1.87, 95% CI: 1.78-1.97). Some variability was observed in the effect on the two outcomes depending on the type of irAE.
这项队列研究评估了免疫检查点抑制剂（ICI）引起的免疫相关不良事件（irAE）与老年非小细胞肺癌（NSCLC）患者死亡率和 ICI 停药之间的关系。使用了 2007 年至 2019 年的监测、流行病学和最终结果-医疗保险链接数据库，并应用具有 irAE 时变暴露的生存分析来估计相关性。总共纳入了 8175 人，其中 46.8%的人发生了 irAE。Cox 回归模型显示，任何 irAE 的发生与死亡率增加相关（HR：1.73，95%CI：1.63-1.82）和治疗中断（HR：1.87，95%CI：1.78-1.97）。根据 irAE 的类型，在对这两个结果的影响上观察到了一些差异。
Zotero 插件