Chen Yina, Peng Shuangyan, Liang Junjie, Wei Ke
Medical School, Hunan University of Chinese Medicine, Changsha, 410208, China.
Hunan Province Key Laboratory of Integrative Pathogen Biology, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, China.
Mol Cell Biochem. 2025 Mar;480(3):1449-1464. doi: 10.1007/s11010-024-05111-z. Epub 2024 Sep 13.
Acute lung injury (ALI) is a continuum of lung changes caused by multiple lung injuries, often associated with severe complications and even death. In ALI, macrophages, alveolar epithelial cells and vascular endothelial cells in the lung are damaged to varying degrees and their function is impaired. Research in recent years has focused on the use of SIRT1 for the treatment of ALI. In this paper, we reviewed the role of SIRT1 in ALI in terms of its cellular and molecular mechanism, targeting of SIRT1 by non-coding RNAs and drug components, as well as pointing out the value of SIRT1 for clinical diagnosis and prognosis. Based on the current literature, SIRT1 exhibits diverse functionalities and possesses significant therapeutic potential. Targeting SIRT1 may provide new therapeutic ideas for the treatment of ALI.
急性肺损伤（ALI）是由多种肺部损伤引起的一系列肺部变化，常伴有严重并发症甚至死亡。在ALI中，肺内的巨噬细胞、肺泡上皮细胞和血管内皮细胞受到不同程度的损伤，其功能受损。近年来的研究集中在使用SIRT1治疗ALI。本文从细胞和分子机制、非编码RNA及药物成分对SIRT1的靶向作用等方面综述了SIRT1在ALI中的作用，并指出了SIRT1在临床诊断和预后方面的价值。基于目前的文献，SIRT1具有多种功能并拥有显著的治疗潜力。靶向SIRT1可能为ALI的治疗提供新的治疗思路。
