Cancer Research UK Scotland Institute, Glasgow, UK.
Cancer Research UK Scotland Institute, Glasgow, UK; School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Cancer Cell. 2024 Oct 14;42(10):1637-1642. doi: 10.1016/j.ccell.2024.08.017. Epub 2024 Sep 12.
γδT cells represent a group of immune cells that are understudied but whose utility has been recognized for cancer immunotherapy purposes. Recent studies have highlighted a critical role for these cells in tumor initiation, growth, and metastasis and revealed an increasingly complex biology of γδT cell subsets that is context and tissue specific. We discuss here how γδT cell subsets are regulated, their interaction with cancer and other immune cells, and the implications from these latest discoveries for people with cancer.
γδT 细胞是一群研究较少但已被确认为癌症免疫治疗用途的免疫细胞。最近的研究强调了这些细胞在肿瘤起始、生长和转移中的关键作用，并揭示了 γδT 细胞亚群的生物学越来越复杂，具有特定的背景和组织特异性。在这里，我们讨论了 γδT 细胞亚群是如何被调节的，它们与癌症和其他免疫细胞的相互作用，以及这些最新发现对癌症患者的意义。
