Schäfer Valentin S, Petzinna Simon M, Schmidt Wolfgang A
Sektion Rheumatologie und Klinische Immunologie, Medizinische Klinik III, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Deutschland.
Abteilung für Rheumatologie und Klinische Immunologie, Immanuel Krankenhaus Berlin, Standort Berlin-Buch, Berlin, Deutschland.
Z Rheumatol. 2024 Dec;83(10):800-811. doi: 10.1007/s00393-024-01565-0. Epub 2024 Sep 13.
Large vessel vasculitis, including giant cell arteritis (GCA) and Takayasu arteritis (TAK), are autoimmune diseases primarily affecting the aorta and its branches. GCA is the most common primary vasculitis. Inflammatory changes in the vessel walls can cause serious complications such as amaurosis, stroke, and aortic dissection and rupture. Imaging techniques have become an integral part for the diagnosis and monitoring of large vessel vasculitis, allowing for effective disease monitoring. GCA and TAK exhibit similar patterns of vascular distribution. However, the temporal arteries are never involved in TAK, and axillary arteritis occurs more frequently in GCA. In most centers, ultrasound of the temporal and axillary arteries has replaced temporal artery biopsy as the primary diagnostic tool for GCA. In addition to ultrasound, magnetic resonance imaging (MRI), computed tomography (CT), and [F]-FDG (fluorodeoxyglucose) positron emission tomography-computed tomography (PET) are important, particularly for visualizing the aorta. Moreover, PET-CT is now also capable of assessing the temporal arteries, although it is not yet widely available. In polymyalgia rheumatica (PMR), ultrasound of the shoulder and hip regions is part of the ACR/EULAR classification criteria. MRI allows detailed visualization of additional inflammatory extraarticular manifestations, showing characteristic inflammatory lesions in entheses, tendons, and ligaments. [F]-FDG-PET-CT also enables the visualization of musculoskeletal inflammation, especially in the shoulder and hip regions, as well as paravertebral areas. Ultrasound can detect subclinical GCA in up to 23% of patients with PMR, which should be treated like GCA. Technological innovations such as new radiotracers and improved MRI imaging could further enhance the diagnosis and monitoring of large vessel vasculitis and PMR, thus playing a crucial role in improving the prognosis through faster initiation of therapy.
大血管血管炎,包括巨细胞动脉炎(GCA)和大动脉炎(TAK),是主要影响主动脉及其分支的自身免疫性疾病。GCA是最常见的原发性血管炎。血管壁的炎症变化可导致严重并发症,如黑矇、中风以及主动脉夹层和破裂。成像技术已成为大血管血管炎诊断和监测不可或缺的一部分,有助于对疾病进行有效监测。GCA和TAK呈现相似的血管分布模式。然而,TAK从不累及颞动脉,而腋动脉炎在GCA中更常见。在大多数医疗中心,颞动脉和腋动脉超声已取代颞动脉活检,成为GCA的主要诊断工具。除超声外,磁共振成像(MRI)、计算机断层扫描(CT)以及[F]-氟脱氧葡萄糖(FDG)正电子发射断层扫描-计算机断层扫描(PET)也很重要,尤其是在显示主动脉方面。此外,PET-CT现在也能够评估颞动脉,尽管其尚未广泛应用。在风湿性多肌痛(PMR)中,肩部和髋部区域的超声检查是美国风湿病学会(ACR)/欧洲抗风湿病联盟(EULAR)分类标准的一部分。MRI能够详细显示其他关节外炎症表现,显示附着点、肌腱和韧带中的特征性炎症病变。[F]-FDG-PET-CT还能够显示肌肉骨骼炎症,尤其是在肩部和髋部区域以及椎旁区域。超声检查在高达23%的PMR患者中可检测到亚临床GCA,这类患者应按GCA进行治疗。新型放射性示踪剂和改进的MRI成像等技术创新可进一步提高大血管血管炎和PMR的诊断与监测水平,从而通过更快开始治疗对改善预后发挥关键作用。