Tuomala R E, Fischer S G, Muñoz A, Souney P F, Steele L, Polk B F
Obstet Gynecol. 1985 Sep;66(3):372-6.
In a randomized, double-blind clinical trial, 208 women who underwent abdominal hysterectomy received either cefazolin (N = 108) or moxalactam (N = 100) as perioperative antimicrobial prophylaxis. There were no differences between the two groups in rates of serious infection, minor wound infection, standard febrile morbidity, duration of hospitalization, proportion receiving other postoperative antibiotics, or rates of rehospitalization. Women who received moxalactam had significantly more urinary tract infections, 87% of which were caused by the enterococcus. It is concluded that perioperative prophylaxis with third-generation cephalosporins is not justified at this time.
在一项随机双盲临床试验中，208例行腹部子宫切除术的女性接受了头孢唑林（N = 108）或拉氧头孢（N = 100）作为围手术期抗菌预防用药。两组在严重感染率、轻微伤口感染率、标准发热发病率、住院时间、接受其他术后抗生素治疗的比例或再次住院率方面均无差异。接受拉氧头孢的女性尿路感染明显更多，其中87%由肠球菌引起。结论是目前围手术期使用第三代头孢菌素进行预防尚无正当理由。
