Falcón-Cordón Soraya, Falcón-Cordón Yaiza, Costa-Rodríguez Noelia, Matos Jorge Isidoro, Montoya-Alonso José Alberto, Carretón Elena
Internal Medicine, Veterinary Medicine and Therapeutic Research Group, Faculty of Veterinary Medicine, Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria (ULPGC), 35016 Las Palmas de Gran Canaria, Spain.
Animals (Basel). 2024 Sep 2;14(17):2551. doi: 10.3390/ani14172551.
Pulmonary hypertension (PH) is a prevalent and severe complication in dogs infected with . This study aimed to elucidate the progression of PH by analyzing radiographic parameters and the Right Pulmonary Artery Distensibility (RPAD) Index at three key time points: diagnosis (day 0), discharge (day 90), and six months post-discharge (day 270). Fifty-two heartworm-infected dogs were divided into two groups: non-hypertensive and hypertensive. Radiographic measurements, including Vertebral Heart Size (VHS), CrPA/R4 ratio, and CdPA/R9 ratio, along with the RPAD Index, were assessed on Days 0, 90, and 270. Results indicated that, in Group A, the RPAD Index improved significantly from 42% on Day 0 to 43.16% on Day 90, with no significant change by Day 270 (42%). In contrast, hypertensive dogs exhibited a persistently low RPAD Index, averaging 17% throughout this study ( < 0.001). Radiographic parameters in hypertensive dogs showed continuous elevation compared to non-hypertensive dogs, with significant increases in VHS, CrPA/R4, and CdPA/R9 ratios on day 270 compared to day 0 ( < 0.05). The results confirmed that PH persisted in dogs with after adulticide treatment, highlighting the importance of regular radiographic monitoring for assessing and managing long-term outcomes in dogs with PH during and after adulticide treatment. Continuous surveillance is thus essential for the effective post-treatment management of PH in dogs.
肺动脉高压（PH）是感染[具体病原体未提及]的犬类中一种普遍且严重的并发症。本研究旨在通过分析三个关键时间点（诊断时（第0天）、出院时（第90天）和出院后六个月（第270天））的影像学参数和右肺动脉扩张性（RPAD）指数来阐明PH的进展情况。52只感染心丝虫的犬被分为两组：非高血压组和高血压组。在第0天、第90天和第270天评估影像学测量指标，包括椎体心脏大小（VHS）、CrPA/R4比值和CdPA/R9比值以及RPAD指数。结果表明，在A组中，RPAD指数从第0天的42%显著提高到第90天的43.16%，到第270天无显著变化（42%）。相比之下，高血压犬的RPAD指数持续较低，在本研究期间平均为17%（<0.001）。与非高血压犬相比，高血压犬的影像学参数持续升高，与第0天相比，第270天的VHS、CrPA/R4和CdPA/R9比值显著增加（<0.05）。结果证实，在进行成虫清除治疗后，犬类中的PH仍然存在，突出了在成虫清除治疗期间和之后定期进行影像学监测对于评估和管理患有PH的犬类长期预后的重要性。因此，持续监测对于犬类PH的有效治疗后管理至关重要。
