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抗中性粒细胞胞浆抗体(ANCA)相关血管炎的复发预测因素

Relapse Predictors in Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis.

作者信息

Wawrzycka-Adamczyk Katarzyna, Korkosz Mariusz, Musiał Jacek, Wójcik Krzysztof

机构信息

Rheumatology, Immunology and Internal Medicine Department, Kraków University Hospital, ul Jakubowskiego 2, 30-688 Kraków, Poland.

Faculty of Medicine, Jagiellonian University Medical College, 31-008 Kraków, Poland.

出版信息

Diagnostics (Basel). 2024 Aug 24;14(17):1849. doi: 10.3390/diagnostics14171849.

Abstract

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are a group of rare diseases with a chronic and relapsing course. Recent treatment guidelines offer many therapeutic options depending mainly on the type of diagnosis and disease manifestations. Areas that remain under discussion include whether all patients diagnosed with AAV belong to a homogeneous group with a similar prognosis at baseline or if the type and duration of remission-inducing treatment should depend on factors other than just diagnosis and disease severity. The aim of this review is to present the recent literature on the tools available to use while evaluating the risk of relapse in patients upon presentation as well as potential biomarkers of proceeding flare in patients upon remission.

摘要

抗中性粒细胞胞浆抗体(ANCA)相关性血管炎(AAV)是一组病程呈慢性且复发的罕见疾病。近期的治疗指南提供了许多治疗选择,主要取决于诊断类型和疾病表现。仍在讨论的领域包括,所有被诊断为AAV的患者在基线时是否属于预后相似的同质群体,或者诱导缓解治疗的类型和持续时间是否应取决于除诊断和疾病严重程度之外的其他因素。本综述的目的是介绍近期关于在评估初诊患者复发风险时可用工具以及缓解期患者病情进展发作潜在生物标志物的文献。

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本文引用的文献

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Urinary CD4 + T Cells Predict Renal Relapse in ANCA-Associated Vasculitis.
J Am Soc Nephrol. 2024 Apr 1;35(4):483-494. doi: 10.1681/ASN.0000000000000311. Epub 2024 Jan 17.
2
Specific IgG glycosylation differences precede relapse in PR3-ANCA associated vasculitis patients with and without ANCA rise.
Front Immunol. 2023 Sep 29;14:1214945. doi: 10.3389/fimmu.2023.1214945. eCollection 2023.
4
EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update.
Ann Rheum Dis. 2024 Jan 2;83(1):30-47. doi: 10.1136/ard-2022-223764.
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Serum Biomarkers of Disease Activity in Longitudinal Assessment of Patients with ANCA-Associated Vasculitis.
ACR Open Rheumatol. 2022 Feb;4(2):168-176. doi: 10.1002/acr2.11366. Epub 2021 Nov 18.
10
Predicting relapse in anti-neutrophil cytoplasmic antibody-associated vasculitis: a Systematic review and meta-analysis.
Rheumatol Adv Pract. 2021 Mar 9;5(3):rkab018. doi: 10.1093/rap/rkab018. eCollection 2021.

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