Bizzoca Maria Eleonora, Caponio Vito Carlo Alberto, Lo Muzio Lorenzo, Claudio Pier Paolo, Cortese Antonio
Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.
Department of Pharmacology and Toxicology, Cancer Center & Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Cancers (Basel). 2024 Aug 29;16(17):3004. doi: 10.3390/cancers16173004.
According to the "cancer stem cell" (CSCs) theory, tumors are a diverse and expanding group of malignant cells that originate from a small number of CSCs. Despite treatment, these cells can still become active and proliferate, which can result in distant metastasis and local recurrences. A new paradigm in cancer treatment involves targeting both CSCs and the cancer cells in a tumor. This review aims to examine the literature on methods published to overcome chemoresistance due to the presence of CSCs in head and neck cancers. The review was registered with PROSPERO (ID# CRD42024512809). After Pub Med, Scopus, and WoS database searches, 31 relevant articles on oral squamous cell carcinoma (OSCC) were selected. Compounds that increased chemosensitivity by targeting CSCs in head and neck squamous cell carcinoma (HNSCC) were divided into (1) natural products, (2) adjuvant molecules to traditional chemotherapy, and (3) CSCs targeting patient-specific fresh biopsies for functional precision medicine.
根据“癌症干细胞”（CSCs）理论，肿瘤是一群多样化且不断扩大的恶性细胞，起源于少数癌症干细胞。尽管进行了治疗，这些细胞仍可变得活跃并增殖，从而导致远处转移和局部复发。癌症治疗的一种新范式涉及同时靶向肿瘤中的癌症干细胞和癌细胞。本综述旨在研究已发表的关于克服头颈部癌症中因癌症干细胞存在而导致的化疗耐药性的方法的文献。该综述已在PROSPERO（ID# CRD42024512809）注册。在对PubMed、Scopus和WoS数据库进行检索后，选择了31篇关于口腔鳞状细胞癌（OSCC）的相关文章。通过靶向头颈部鳞状细胞癌（HNSCC）中的癌症干细胞来提高化疗敏感性的化合物分为三类：（1）天然产物，（2）传统化疗的辅助分子，以及（3）用于功能精准医学的靶向癌症干细胞的患者特异性新鲜活检样本。
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