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载双药纳米转铁蛋白体经诱导细胞周期停滞和凋亡实现光动力-化学疗法联合治疗黑素瘤的经皮递药研究

Topical Delivery of Dual Loaded Nano-Transfersomes Mediated Chemo-Photodynamic Therapy against Melanoma via Inducing Cell Cycle Arrest and Apoptosis.

机构信息

State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

出版信息

Int J Mol Sci. 2024 Sep 5;25(17):9611. doi: 10.3390/ijms25179611.

DOI:10.3390/ijms25179611
PMID:39273560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11394987/
Abstract

Melanoma is a malignant skin cancer associated with high mortality rates and drug resistance, posing a significant threat to human health. The combination of chemotherapy and photodynamic therapy (PDT) represents a promising strategy to enhance antitumor efficacy through synergistic anti-cancer effects. Topical delivery of chemotherapeutic drugs and photosensitizers (PS) offers a non-invasive and safe way to treat melanoma. However, the effectiveness of these treatments is often hindered by challenges such as limited skin permeability and instability of the PS. In this study, transfersomes (TFS) were designed to facilitate transdermal delivery of the chemotherapeutic drug 5-Fluorouracil (5-FU) and the PS Imperatorin (IMP) for combined chemo-photodynamic therapy for melanoma. The cytotoxic and phototoxic effects of TFS-mediated PDT (TFS-UVA) were investigated in A375 cells and nude mice. The study also demonstrated that TFS-UVA generated intracellular ROS, induced G2/ M phase cell cycle arrest, and promoted cell apoptosis. In conclusion, this study indicated that 5-FU/ IMP-TFS serves as an effective transdermal therapeutic strategy for chemo-PDT in treating melanoma.

摘要

黑色素瘤是一种恶性皮肤癌，死亡率高且易产生耐药性，对人类健康构成重大威胁。化疗与光动力疗法（PDT）的联合应用代表了一种通过协同抗癌作用来提高抗肿瘤疗效的有前途的策略。通过化学疗法药物和光增敏剂（PS）的局部递送，为治疗黑色素瘤提供了一种非侵入性和安全的方法。然而，这些治疗方法的有效性常常受到皮肤通透性有限和 PS 不稳定性等挑战的限制。在本研究中，设计了转体（TFS）以促进化学疗法药物 5-氟尿嘧啶（5-FU）和 PS 白芷素（IMP）的经皮递送至黑色素瘤的联合化疗-光动力疗法。研究了 TFS 介导的 PDT（TFS-UVA）对 A375 细胞和裸鼠的细胞毒性和光毒性作用。该研究还表明，TFS-UVA 产生了细胞内 ROS，诱导了 G2/M 期细胞周期停滞，并促进了细胞凋亡。总之，本研究表明 5-FU/IMP-TFS 是治疗黑色素瘤的化疗-PDT 的一种有效经皮治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d1/11394987/70241f2ecb0e/ijms-25-09611-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d1/11394987/70241f2ecb0e/ijms-25-09611-g008.jpg
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2
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3
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4
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5
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7
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