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叶片精油的成分表征及其抗炎活性机制

Composition Characterization of Leaf Essential Oil and Its Anti-Inflammatory Activity Mechanisms.

作者信息

Lin Chia-Hsin, Chiang Yu-Ting, Lin Li-Yin, Tsao Nai-Wen, Wang Chung-Hsuan, Chien Shih-Chang, Sun Ying-Hsuan, Wang Sheng-Yang

机构信息

Department of Forestry, National Chung Hsing University, Taichung 402202, Taiwan.

Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404328, Taiwan.

出版信息

Plants (Basel). 2024 Sep 6;13(17):2506. doi: 10.3390/plants13172506.

DOI:10.3390/plants13172506
PMID:39273990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11397578/
Abstract

This study investigates the composition characteristics and anti-inflammatory activity mechanisms of the essential oil from the leaves of . is a perennial herb commonly found in East Asia, traditionally used to treat various ailments. The essential oil extracted through water distillation, primarily contains 1,8-cineole (13.73%), santolina triene (13.53%), and germacrene D (10.67%). Three compounds were identified from the essential oil, namely 1-acetoxy-2-(2-hydroxypropyl)-5-methylhex-3,5-diene, 1-acetoxy-isopyliden-hex-5-en-4-one, and chrysanthemyl acetate, with the first two being newly discovered compounds. Then, the essential oil of exhibits significant anti-inflammatory effects on RAW264.7 macrophages, effectively inhibiting the production of NO and ROS, with the IC50 value of 10.3 μg/mL. Furthermore, the essential oil reduces the expression of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β. Mechanistic studies indicate that the essential oil affects the inflammatory response by inhibiting the expression of iNOS but has no significant impact on COX-2. Further analysis suggests that the essential oil may regulate the inflammatory response through the ERK protein in the MAPK pathway and IκBα in the NF-κB pathway, while also promoting the activity of the NRF2/HO-1 antioxidant pathway, enhancing the cell's antioxidant capacity, thereby achieving an effect of inhibiting the inflammatory response. These results highlight the potential application value of leaf essential oil in the medical and healthcare fields.

摘要

本研究调查了[植物名称]叶片精油的成分特征及其抗炎活性机制。[植物名称]是一种常见于东亚的多年生草本植物，传统上用于治疗各种疾病。通过水蒸馏提取的精油主要含有1,8-桉叶素（13.73%）、三烯山道年（13.53%）和吉马烯D（10.67%）。从该精油中鉴定出三种化合物，即1-乙酰氧基-2-(2-羟丙基)-5-甲基己-3,5-二烯、1-乙酰氧基-异亚丙基己-5-烯-4-酮和乙酸菊酯，前两种为新发现的化合物。然后，[植物名称]精油对RAW264.7巨噬细胞具有显著的抗炎作用，能有效抑制NO和ROS的产生，IC50值为10.3μg/mL。此外，该精油还能降低促炎细胞因子如TNF-α、IL-6和IL-1β的表达。机制研究表明，该精油通过抑制iNOS的表达影响炎症反应，但对COX-2没有显著影响。进一步分析表明，该精油可能通过丝裂原活化蛋白激酶（MAPK）途径中的ERK蛋白和核因子κB（NF-κB）途径中的IκBα调节炎症反应，同时还能促进NRF2/HO-1抗氧化途径的活性，增强细胞的抗氧化能力，从而达到抑制炎症反应的效果。这些结果突出了[植物名称]叶片精油在医疗保健领域的潜在应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3215/11397578/a80b7b822704/plants-13-02506-g011.jpg
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本文引用的文献

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Molecules. 2023 Dec 15;28(24):8108. doi: 10.3390/molecules28248108.
2
Citrulline inhibits LPS-induced pyroptosis of RAW264.7 macrophages through NF-κB signaling pathway.瓜氨酸通过 NF-κB 信号通路抑制 LPS 诱导的 RAW264.7 巨噬细胞焦亡。
Immun Inflamm Dis. 2023 Apr;11(4):e832. doi: 10.1002/iid3.832.
3
Combined Anti-Adipogenic Effects of Hispidulin and -Synephrine on 3T3-L1 Adipocytes.
槐皮素和辛弗林联合抗 3T3-L1 脂肪细胞形成作用。
Biomolecules. 2021 Nov 25;11(12):1764. doi: 10.3390/biom11121764.
4
Hostaflavone A from Hosta plantaginea (Lam.) Asch. blocked NF-κB/iNOS/COX-2/MAPKs/Akt signaling pathways in LPS-induced RAW 264.7 macrophages.来自玉簪（Hosta plantaginea (Lam.) Asch.）的玉簪黄酮A阻断了脂多糖诱导的RAW 264.7巨噬细胞中的NF-κB/iNOS/COX-2/MAPKs/Akt信号通路。
J Ethnopharmacol. 2022 Jan 10;282:114605. doi: 10.1016/j.jep.2021.114605. Epub 2021 Sep 8.
5
Lipoxygenase (LOX) Pathway: A Promising Target to Combat Cancer.脂氧合酶（LOX）通路：抗肿瘤的有希望靶点。
Curr Pharm Des. 2021 Oct 5;27(31):3349-3369. doi: 10.2174/1381612826666210101153216.
6
Natural COX-2 Inhibitors as Promising Anti-inflammatory Agents: An Update.天然 COX-2 抑制剂作为有前途的抗炎药：最新进展。
Curr Med Chem. 2021;28(18):3622-3646. doi: 10.2174/0929867327999200917150939.
7
Asiaticoside Alleviates Cerebral Ischemia-Reperfusion Injury via NOD2/Mitogen-Activated Protein Kinase (MAPK)/Nuclear Factor kappa B (NF-κB) Signaling Pathway.积雪草苷通过 NOD2/丝裂原活化蛋白激酶（MAPK）/核因子 kappa B（NF-κB）信号通路减轻脑缺血再灌注损伤。
Med Sci Monit. 2020 Feb 1;26:e920325. doi: 10.12659/MSM.920325.
8
The role of JAK/STAT signaling pathway and its inhibitors in diseases.JAK/STAT 信号通路及其抑制剂在疾病中的作用。
Int Immunopharmacol. 2020 Mar;80:106210. doi: 10.1016/j.intimp.2020.106210. Epub 2020 Jan 20.
9
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10
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J Cell Physiol. 2019 Jul;234(7):10625-10639. doi: 10.1002/jcp.27739. Epub 2018 Nov 13.