Ehongo Adèle, Jawdat De Togme Georgina, De Maertelaer Viviane
Hôpital Universitaire de Bruxelles (HUB), CUB Hôpital Erasme, Service d'Ophtalmologie, Route de Lennik 808, 1070 Bruxelles, Belgium.
Biostatistics, IRIBHM Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070 Bruxelles, Belgium.
J Clin Med. 2024 Aug 23;13(17):4978. doi: 10.3390/jcm13174978.
Posterior staphyloma (PS) is a hallmark of pathological myopia, corresponding to a circumscribed outpouching of the eyeball with choroidal thinning and inward scleral deformation at its edges. Its pathogenesis is still unclear, thus constituting a research priority as the prevalence of myopia is increasing worldwide. Recently, it has been suggested that the optic nerve sheaths or oblique muscles are potential promoters of PS through the traction or compression effect that they apply to the eye wall. The inferior oblique muscle (IOM) inserts 1-2 mm from the macula. The projection of its insertion is accessible using Optical Coherence Tomography (OCT). Before launching prospective studies, we sought to detect any choroidal thinning (ChT) in the temporal vicinity of the macula and to measure the distance between it and the fovea (FT-distance). : This retrospective cross-sectional pilot study included 120 eyes. Using Spectralis-OCT, the area centered by the Bruch's membrane opening-fovea axis was analyzed for ChT and FT-distance. : Of the 112 defined eyes, 70% (78 eyes) had ChT. Pachymetry was significantly thinner ( = 0.018) in eyes with than without ChT. The mean FT-distance was 3601.9 ± 93.6 µm. The location of ChT coincided with the insertion distance of the IOM, suggesting a link between them. The association between the presence of ChT and a thinner pachymetry suggests a reduced scleral resistance, as a thinner pachymetry is related to a thinner sclera. Our results suggest a link between ocular deformation and the IOM, which may be relevant for the pathogenesis of PS, warranting further investigation.
后巩膜葡萄肿（PS）是病理性近视的一个标志，对应于眼球的局限性外凸，其边缘脉络膜变薄且巩膜向内变形。其发病机制仍不清楚，因此随着全球近视患病率的增加，这已成为一个研究重点。最近，有人提出视神经鞘或眼外肌通过它们对眼壁施加的牵引或压迫作用，可能是PS的潜在促进因素。下斜肌（IOM）在距黄斑1 - 2毫米处附着。使用光学相干断层扫描（OCT）可以获取其附着点的投影。在开展前瞻性研究之前，我们试图检测黄斑颞侧附近的脉络膜变薄情况（ChT），并测量其与中央凹之间的距离（FT距离）。这项回顾性横断面试点研究纳入了120只眼。使用Spectralis - OCT，以布鲁赫膜开口 - 中央凹轴为中心的区域进行ChT和FT距离分析。在112只明确的眼中，70%（78只眼）有ChT。有ChT的眼的角膜厚度测量值显著更薄（= 0.018）。平均FT距离为3601.9±93.6微米。ChT的位置与IOM的附着距离一致，提示它们之间存在联系。ChT的存在与更薄的角膜厚度测量值之间的关联表明巩膜阻力降低，因为更薄的角膜厚度测量值与更薄的巩膜有关。我们的结果提示眼球变形与IOM之间存在联系，这可能与PS的发病机制相关，值得进一步研究。
