雷诺嗪揭秘：以新视角重新发现一种旧疗法。
Ranolazine Unveiled: Rediscovering an Old Solution in a New Light.
作者信息
De Santis Giulia Azzurra, De Ferrari Tommaso, Parisi Francesca, Franzino Marco, Molinero Agustin Ezequiel, Di Carlo Alessandro, Pistelli Lorenzo, Vetta Giampaolo, Parlavecchio Antonio, Torre Marco, Parollo Matteo, Mansi Giacomo, Tamborrino Pietro Paolo, Canu Antonio, Grifoni Gino, Segreti Luca, Di Cori Andrea, Viani Stefano Marco, Zucchelli Giulio
机构信息
Cardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.
Clinical Cardiology and Heart Failure Unit, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), 90127 Palermo, Italy.
出版信息
J Clin Med. 2024 Aug 23;13(17):4985. doi: 10.3390/jcm13174985.
Ranolazine is an anti-anginal medication that has demonstrated antiarrhythmic properties by inhibiting both late sodium and potassium currents. Studies have shown promising results for ranolazine in treating both atrial fibrillation and ventricular arrhythmias, particularly when used in combination with other medications. This review explores ranolazine's mechanisms of action and its potential role in cardiac arrhythmias treatment in light of previous clinical studies.
雷诺嗪是一种抗心绞痛药物，已通过抑制晚期钠电流和钾电流显示出抗心律失常特性。研究表明，雷诺嗪在治疗心房颤动和室性心律失常方面取得了有前景的结果，尤其是与其他药物联合使用时。鉴于先前的临床研究，本综述探讨了雷诺嗪的作用机制及其在心律失常治疗中的潜在作用。
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