Chewaskulyong Busyamas, Malairungsakul Haritchanan, Buranapin Supawan, Jesadaporn Panas, Ketpueak Thanika, Suksombooncharoen Thatthan, Charoentum Chaiyut
Division of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
J Clin Med. 2024 Sep 4;13(17):5236. doi: 10.3390/jcm13175236.
Malnutrition harms treatment outcomes, QoL, and survival in lung cancer patients. Effective dietary counseling can improve nutrition, but few randomized controlled trials have focused on lung cancer patients. The objective of this study was to determine if dietary counseling improves nutritional and treatment outcomes when compared to routine care. : This open-label parallel RCT was conducted at Maharaj Nakorn Chiang Mai Hospital in Thailand. The investigators used computer-generated blocked randomization to assign patients to dietary counseling by a nutritionist or routine care. The nutritionist sessions occurred before treatment, with follow-ups at 3-4 weeks and 12 weeks. The primary outcome was the mean percentage change in the body weight of patients at 12 weeks. Secondary outcomes included changes in the BMI, nutrition score, QoL, serum albumin level, lymphocyte count, energy and protein intake, treatment response, PFS, and OS. : Between April 2020 and May 2022, after completing recruitment, 80 lung cancer patients were randomized: 43 to dietary counseling and 37 to routine care. The dietary counseling group showed significant benefits, with smaller decreases in body weight at 3-4 weeks (-0.8% vs. -2.6%, = 0.05) and 12 weeks (-1.1% vs. -4.3%, = 0.05). They also had higher energy and protein intake levels and better treatment response rates. The secondary outcomes and significant adverse events did not differ significantly between the groups. : Dietary counseling helps to maintain body weight, maintain dietary intake, and enhance treatment responses in lung cancer patients. Although not all nutritional markers or survival outcomes were affected, these findings highlight the importance of early nutritional interventions.
营养不良会损害肺癌患者的治疗效果、生活质量和生存率。有效的饮食咨询可以改善营养状况，但很少有随机对照试验关注肺癌患者。本研究的目的是确定与常规护理相比，饮食咨询是否能改善营养和治疗效果。：这项开放标签的平行随机对照试验在泰国清迈玛哈叻吉医院进行。研究人员使用计算机生成的区组随机化方法，将患者分配到由营养师提供的饮食咨询组或常规护理组。营养师的咨询在治疗前进行，在3 - 4周和12周进行随访。主要结局是患者在12周时体重的平均变化百分比。次要结局包括体重指数、营养评分、生活质量、血清白蛋白水平、淋巴细胞计数、能量和蛋白质摄入量、治疗反应、无进展生存期和总生存期的变化。：在2020年4月至2022年5月完成招募后，80例肺癌患者被随机分组：43例接受饮食咨询，37例接受常规护理。饮食咨询组显示出显著益处，在3 - 4周时体重下降幅度较小（-0.8%对-2.6%，P = 0.05），在12周时体重下降幅度也较小（-1.1%对-4.3%，P = 0.05）。他们还具有更高的能量和蛋白质摄入量水平以及更好的治疗反应率。两组之间的次要结局和显著不良事件没有显著差异。：饮食咨询有助于维持肺癌患者的体重、保持饮食摄入量并增强治疗反应。尽管并非所有营养指标或生存结局都受到影响，但这些发现凸显了早期营养干预的重要性。
