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阻塞性睡眠呼吸暂停低通气综合征、神经发育与里氏头影测量法之间关系的初步研究

A Pilot Study on the Relationship between Obstructive Sleep Apnoea-Hypopnea Syndrome, Neurodevelopment, and Ricketts' Cephalometry.

作者信息

Robayna Teresa I González, Martínez Carlos Pérez-Albacete, Gandía Jesús M, Martínez Mª Dolores Austro, Pérez Ángela Sempere, Cascales Raúl Ferrando

机构信息

UCAM Faculty of Dentistry, University Campus Los Jerónimos, Catholic University of Murcia, 135 Guadalupe, 30107 Murcia, Spain.

Department of Mathematics, Physics and Technological Sciences, CEU University Cardenal Herrera, 03202 Elche, Spain.

出版信息

J Clin Med. 2024 Sep 5;13(17):5274. doi: 10.3390/jcm13175274.

Abstract

: The aim of this research is to achieve the early detection of facial characteristics in patients diagnosed with neurodevelopmental deficits and obstructive sleep apnoea-hypopnea syndrome (OSAHS) through the analysis of the VERT index and Ricketts' cephalometry to minimise the neurocognitive morbidity associated with these disorders. : This clinical study was conducted on 44 patients aged 4 to 15 years. Participants completed an initial questionnaire about sleep disturbances, followed by a polysomnography, a radiographic study, and an oral examination. : The maximum variability in the data was obtained in the mandibular plane angle, where we observed that the measurement was higher in patients diagnosed with OSAHS. The relative and normalised indices of facial depth and the mandibular plane showed variations between patients with a clinical picture compatible with OSAHS and the control group without pathology. : Our findings indicate that Ricketts' VERT index by itself is unable to provide evidence of a diagnosis compatible with OSAHS in patients with early neurodevelopmental deficits, but, after analysing the results obtained, we observed that for the cephalometric measurements of the mandibular plane angle and facial depth relative to the patient's age, there are sufficiently strong variations for creating a solid method of differential diagnosis, thus preventing complications at the neurocognitive level.

摘要

本研究的目的是通过分析VERT指数和里克茨头影测量法,实现对诊断为神经发育缺陷和阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者面部特征的早期检测,以尽量减少与这些疾病相关的神经认知发病率。

这项临床研究对44名4至15岁的患者进行。参与者首先完成了一份关于睡眠障碍的初始问卷,随后进行了多导睡眠图检查、影像学研究和口腔检查。

数据中的最大变异性出现在下颌平面角,我们观察到诊断为OSAHS的患者该测量值更高。面部深度和下颌平面的相对指数及标准化指数在临床表现符合OSAHS的患者与无病变的对照组之间存在差异。

我们的研究结果表明,里克茨VERT指数本身无法为早期神经发育缺陷患者提供与OSAHS相符的诊断证据,但在分析所得结果后,我们观察到,对于下颌平面角和相对于患者年龄的面部深度的头影测量,存在足够明显的差异,足以建立一种可靠的鉴别诊断方法,从而预防神经认知层面的并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abf3/11396744/b9c2b9243997/jcm-13-05274-g001.jpg

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