Pasternak R D, Marks R L, Hubbs S J, DiPasquale G
Res Commun Chem Pathol Pharmacol. 1985 Jun;48(3):353-67.
Splenic lymphoid cells from rats with adjuvant induced polyarthritis show a diminished response to the T-cell mitogens Con A and PHA. This report describes the in vitro effects of various antirheumatic agents on the mitogen induced proliferative response of normal (NSC) and arthritic (ASC) rat spleen cells. Indomethacin enhanced only the arthritic responses. Other PG synthesis inhibitors such as ibuprofen and naproxen enhanced the arthritic as well as the normal spleen cell proliferative responses. Gold sodium thiomalate augmented arthritic but not normal blastogenesis. Penicillamine significantly enhanced only the Con A response of arthritic cells at 10(7)M. Levamisole produced a significant increase in the PHA response of arthritic cells and the Con A NSC response. Chloroquine diphosphate enhanced the Con A response of normal cells at 10(-5)M and 10(-6)M; both chloroquine and tilorone suppressed blastogenesis of arthritic spleen cells at 10(-4)M and 10(-5)M. When classifying antirheumatic agents as stimulator or suppressors of immune function, one must account for their effects on arthritic as well as normal lymphoid cells at the predicted pharmacologic plasma levels.
佐剂诱导性多关节炎大鼠的脾淋巴细胞对T细胞丝裂原刀豆蛋白A（Con A）和植物血凝素（PHA）的反应减弱。本报告描述了各种抗风湿药对正常（NSC）和关节炎（ASC）大鼠脾细胞丝裂原诱导的增殖反应的体外作用。吲哚美辛仅增强了关节炎反应。其他前列腺素合成抑制剂，如布洛芬和萘普生，增强了关节炎以及正常脾细胞的增殖反应。硫代苹果酸金钠增强了关节炎细胞的增殖，但对正常细胞无此作用。青霉胺在10⁻⁷M时仅显著增强了关节炎细胞对Con A的反应。左旋咪唑使关节炎细胞对PHA的反应以及正常脾细胞对Con A的反应显著增加。二磷酸氯喹在10⁻⁵M和10⁻⁶M时增强了正常细胞对Con A的反应；氯喹和泰洛龙在10⁻⁴M和10⁻⁵M时均抑制了关节炎脾细胞的增殖。在将抗风湿药分类为免疫功能的刺激剂或抑制剂时，必须考虑它们在预测的药理血浆水平下对关节炎以及正常淋巴细胞的作用。
