Gralnick H R, Williams S B, McKeown L P, Krizek D M, Shafer B C, Rick M E
Thromb Res. 1985 Jun 15;38(6):623-33. doi: 10.1016/0049-3848(85)90205-1.
Platelet von Willebrand factor (vWf) was compared to its plasma counterpart. The platelet vWf was different from plasma vWf in that the multimeric organization was different, larger multimers were present, and the ratio of vWf activity to antigen was higher. Platelet and plasma vWf were similar in their antigenic reactivity in the electroimmunoassay and by liquid phase radioimmunoassay. The amount of vWf activity in large platelets was significantly higher than in normal platelets while the antigen content, although somewhat higher, was not significant. These studies show differences between normal platelet and plasma vWf, and also suggest that platelet size must be considered when platelet vWf is measured in disease states.
将血小板中的血管性血友病因子（vWf）与其血浆中的对应物进行了比较。血小板vWf与血浆vWf不同，在于其多聚体结构不同，存在更大的多聚体，且vWf活性与抗原的比率更高。在免疫电泳测定和液相放射免疫测定中，血小板和血浆vWf的抗原反应性相似。大血小板中的vWf活性量显著高于正常血小板，而抗原含量虽然略高，但并不显著。这些研究显示了正常血小板和血浆vWf之间的差异，也表明在疾病状态下测量血小板vWf时必须考虑血小板大小。
