Department of Cell Biology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 819-0395, Japan.
Nutrients. 2024 Sep 2;16(17):2947. doi: 10.3390/nu16172947.
Recent studies have reported the benefits of food-derived peptides for memory dysfunction. Beyond the physiological effects of peptides, their bioavailability to the brain still remains unclear since the blood-brain barrier (BBB) strictly controls the transportation of compounds to the brain. Here, updated transportation studies on BBB transportable peptides are introduced and evaluated using in vitro BBB models, in situ perfusion, and in vivo mouse experiments. Additionally, the mechanisms of action of brain health peptides in relation to the pathogenesis of neurodegenerative diseases, particularly Alzheimer's disease, are discussed. This discussion follows a summary of bioactive peptides with neuroprotective effects that can improve cognitive decline through various mechanisms, including anti-inflammatory, antioxidative, anti-amyloid β aggregation, and neurotransmitter regulation.
最近的研究报告了食物衍生肽对记忆功能障碍的益处。除了肽的生理作用外，由于血脑屏障（BBB）严格控制化合物向大脑的运输，其脑内生物利用度仍不清楚。本文通过体外 BBB 模型、原位灌流和体内小鼠实验，介绍和评估了最新的 BBB 可转运肽的转运研究。此外，还讨论了脑健康肽在与神经退行性疾病（特别是阿尔茨海默病）发病机制相关的作用机制。讨论内容总结了具有神经保护作用的生物活性肽，这些肽可以通过多种机制改善认知能力下降，包括抗炎、抗氧化、抗β-淀粉样蛋白聚集和神经递质调节。
