IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy.
Units of Diabetology, ASUR Marche, Via Augusto Murri 21, 63900 Fermo, Italy.
Nutrients. 2024 Sep 3;16(17):2976. doi: 10.3390/nu16172976.
INTRODUCTION/AIM: Vitamin D plays a crucial role in immune modulation, which may influence the development of graft-versus-host disease (GvHD) in patients undergoing hematopoietic stem cell transplantation (HSCT). This study aims to evaluate the impact of vitamin D levels and supplementation on the incidence of GvHD in HSCT patients.
A narrative review was conducted across PubMed/Medline, Cochrane Library, CINAHL, and Embase databases.
The reviewed studies indicated widespread vitamin D deficiency among HSCT patients, with baseline levels ranging from 12.8 to 29.2 ng/mL. Supplementation protocols varied significantly, with dosages ranging from 1000 IU/day to 60,000 IU/week. Post-supplementation levels improved in some studies. Studies exploring the relationship between vitamin D and GvHD showed mixed results. Lower baseline vitamin D levels were associated with an increased risk of acute GvHD in some studies, while others found no significant correlation. However, a significant association between low levels of vitamin D and the incidence of chronic GvHD was observed.
Vitamin D deficiency is prevalent in HSCT patients and may influence the risk of developing chronic GvHD. Future research should focus on larger and more rigorous studies to determine the optimal role of vitamin D as an adjuvant therapy in the context of HSCT.
简介/目的：维生素 D 在免疫调节中起着至关重要的作用，这可能会影响接受造血干细胞移植 (HSCT) 的患者发生移植物抗宿主病 (GvHD)。本研究旨在评估维生素 D 水平和补充对 HSCT 患者 GvHD 发生率的影响。
对 PubMed/Medline、Cochrane 图书馆、CINAHL 和 Embase 数据库进行了叙述性综述。
综述研究表明，HSCT 患者普遍存在维生素 D 缺乏，基线水平为 12.8-29.2ng/mL。补充方案差异很大，剂量从 1000IU/天到 60000IU/周不等。一些研究中补充后的水平有所改善。研究维生素 D 与 GvHD 之间关系的研究结果不一。一些研究表明，较低的基线维生素 D 水平与急性 GvHD 的风险增加有关，而其他研究则没有发现显著相关性。然而，观察到维生素 D 水平低与慢性 GvHD 的发生率之间存在显著关联。
HSCT 患者普遍存在维生素 D 缺乏，这可能会影响发生慢性 GvHD 的风险。未来的研究应集中在更大和更严格的研究上，以确定维生素 D 作为 HSCT 辅助治疗的最佳作用。
