Shea J J
Acta Otorhinolaryngol Belg. 1985;39(3):613-9.
Tinnitus is the subjective perception of sound that does not exist. Tinnitus is caused by an altered discharge in the auditory pathway from hair cell to cortex and back. Intravenous Xylocaine acts by blocking 10% of the transmission through each synapse, having more effect on the slow multisynaptic pathway through the reticular formation than the rapid pathway to have more effect on the low frequency slow pathway tinnitus than the rapid pathway high frequency tinnitus. Tocainide, the oral amide of Xylocaine, is of great value in the treatment of tinnitus responsive to intravenous Xylocaine.
耳鸣是对不存在声音的主观感知。耳鸣是由从毛细胞到皮层再返回的听觉通路中放电改变所引起的。静脉注射利多卡因通过阻断每个突触10%的传导来发挥作用，对通过网状结构的缓慢多突触通路的影响比对快速通路的影响更大，对低频缓慢通路耳鸣的影响比对快速通路高频耳鸣的影响更大。妥卡尼，即利多卡因的口服酰胺，在治疗对静脉注射利多卡因有反应的耳鸣方面具有重要价值。
