神经科长新冠：疲劳、自主神经功能紊乱、抑郁和主观记忆主诉之间的关联。
Neurological long-COVID: Associations among fatigue, dysautonomia, depression, and subjective memory complaints.
机构信息
Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste - ASUGI, University of Trieste, Strada di Fiume, Trieste 447-34149, Italy.
Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste - ASUGI, University of Trieste, Strada di Fiume, Trieste 447-34149, Italy.
出版信息
Clin Neurol Neurosurg. 2024 Nov;246:108522. doi: 10.1016/j.clineuro.2024.108522. Epub 2024 Aug 31.
INTRODUCTION
Long-COVID is a multisystem disease characterized by a varied presentation of symptoms. According to most recent research, the most common symptom of long-COVID is fatigue, which up to this date lacks a universally accepted definition. This study aimed to investigate neurocognitive and physical manifestations of neurological long-COVID, particularly fatigue and its relation with autonomic disfunction, cognitive impairment (known as, brain fog), and depressive symptoms. Furthermore, the study provided insights into predictors of fatigue in long-COVID.
METHODS
The included patients (n=141) were referred to the neuro-long-COVID ambulatory service of Trieste from 30 September 2021-02 March 2022. Patients were given self-reporting questionnaires to screen for fatigue, autonomic dysfunction, cognitive impairment and depressive symptoms. The questionnaires adopted for these conditions to be assessed were Fatigue Severity Scale (FSS), COMPASS-31, Prospective-Retrospective Memory Questionnaire (PRMQ), and Beck Depression Inventory (BDI). Participants were divided into two groups, fatigued and non-fatigued patients, based on FSS scoring (scores > 4.67 indicate fatigued patients). The questionnaire scores of the two groups were then compared.
RESULTS
Fatigued patients had significantly higher scores in COMPASS (p<0.001, Cohen's d=1.077), BDI (p<0.001, Cohen's d=0.862), and PRMQ ( p<0.001, Cohen's d=1.159). Furthermore, the multivariate regression analysis showed that predictors of fatigue in long-COVID were symptomatological burden in acute infection (OR=1.38, 95 % CI 1.020-1.887, p=0.037) and in long-COVID (OR=1.78, 95 % CI 1.133-2.2824, p=0.013), COMPASS-31>16 (OR=3.44, 95 % CI 1240-9.560, p=0.018) and BDI>15 (OR=5.1, 95 % CI 1.715-15.164, p=0.003).
CONCLUSION
This study showed associations between fatigue, dysautonomia and depression, as well as with symptom burden in acute and long-COVID.
简介
长新冠是一种多系统疾病，其特征是症状表现多样。根据最近的研究，长新冠最常见的症状是疲劳，而迄今为止，疲劳还没有一个被普遍接受的定义。本研究旨在调查长新冠的神经认知和身体表现，特别是疲劳及其与自主功能障碍、认知障碍（即“脑雾”）和抑郁症状的关系。此外，该研究还探讨了长新冠疲劳的预测因素。
方法
本研究纳入了 2021 年 9 月 30 日至 2022 年 2 月期间，从的里雅斯特神经长新冠门诊转介来的 141 名患者。患者接受了自我报告问卷，以筛查疲劳、自主功能障碍、认知障碍和抑郁症状。用于评估这些情况的问卷包括疲劳严重程度量表（FSS）、COMPASS-31、前瞻性-回顾性记忆问卷（PRMQ）和贝克抑郁量表（BDI）。根据 FSS 评分（评分>4.67 表示疲劳患者），将患者分为疲劳组和非疲劳组。然后比较两组的问卷评分。
结果
疲劳组患者的 COMPASS（p<0.001，Cohen's d=1.077）、BDI（p<0.001，Cohen's d=0.862）和 PRMQ（p<0.001，Cohen's d=1.159）评分明显更高。此外，多元回归分析显示，长新冠疲劳的预测因素是急性感染时的症状负担（OR=1.38，95%CI 1.020-1.887，p=0.037）和长新冠时的症状负担（OR=1.78，95%CI 1.133-2.2824，p=0.013）、COMPASS-31>16（OR=3.44，95%CI 1240-9.560，p=0.018）和 BDI>15（OR=5.1，95%CI 1.715-15.164，p=0.003）。
结论
本研究表明，疲劳与自主神经功能障碍和抑郁有关，也与急性和长新冠时的症状负担有关。
Zotero 插件