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基于社区的澳式原住民痴呆风险管控与预防项目(DAMPAA):一项随机对照试验研究方案。

Community-based dementia risk management and prevention program for Aboriginal Australians (DAMPAA): a randomised controlled trial study protocol.

机构信息

Centre for Aboriginal Medical and Dental Health, The University of Western Australia, Perth, Western Australia, Australia

Centre for Aboriginal Medical and Dental Health, The University of Western Australia, Perth, Western Australia, Australia.

出版信息

BMJ Open. 2024 Sep 13;14(9):e088281. doi: 10.1136/bmjopen-2024-088281.

DOI:10.1136/bmjopen-2024-088281
PMID:39277208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11404219/
Abstract

INTRODUCTION

Aboriginal and Torres Strait Islander peoples are the First Peoples of Australia. Up to 45% of dementia in these populations is due to potentially modifiable risk factors. The Dementia Prevention and Risk Management Program for Aboriginal Australians (DAMPAA) is an Aboriginal Health Practitioner led programme that aims to reduce cognitive decline and functional impairment in older Aboriginal people.

METHODS

Design: DAMPAA is a multisite, randomised controlled trial aiming to deliver and evaluate a culturally appropriate risk factor management programme.

POPULATION

Community-dwelling Aboriginal people aged 45-90 years.

INTERVENTION

Participants will be randomly assigned to either usual care (control) or to a group programme comprising exercise and health education yarning sessions and pharmacist-delivered medication reviews delivered over a 12-month period.

PRIMARY OUTCOME

Cognitive function (Kimberley Indigenous Cognitive Assessment (KICA)-Cog score), daily function (KICA-Activities of Daily Living (ADL) score) and quality of life (Good Spirit, Good Life and EQ-5D-5L scores).

SECONDARY OUTCOMES

Process evaluation interviews, cardiovascular risk factors, falls and death. Process evaluation will be conducted with qualitative methods. Quantitative outcomes will be analysed with generalised linear mixed models.

ETHICS AND DISSEMINATION

The study was approved by the Western Australian Aboriginal Health Ethics Committee and the University of Western Australia Human Research Ethics Committee. Study results will be published in peer-reviewed journals and presented at scientific meetings. We will also develop and disseminate a comprehensive DAMPAA toolkit for health services. The study's findings will guide future prevention strategies and outline a comprehensive process evaluation that may be useful in other Aboriginal health research to contextualise findings.

摘要

简介

原住民和托雷斯海峡岛民是澳大利亚的第一民族。在这些人群中,高达 45%的痴呆症是由潜在可改变的风险因素引起的。澳大利亚原住民的痴呆症预防和风险管理计划(DAMPAA)是一个由原住民卫生从业者领导的项目,旨在减少老年原住民的认知能力下降和功能障碍。

方法

设计:DAMPAA 是一项多地点、随机对照试验,旨在提供和评估一种文化上适当的风险因素管理计划。

人群

45-90 岁的社区居住的原住民。

干预

参与者将被随机分配到常规护理(对照组)或小组计划,包括运动和健康教育谈话以及药剂师提供的药物审查,为期 12 个月。

主要结果

认知功能(金伯利原住民认知评估(KICA)-认知评分)、日常功能(KICA-日常生活活动(ADL)评分)和生活质量(良好精神、良好生活和 EQ-5D-5L 评分)。

次要结果

过程评估访谈、心血管风险因素、跌倒和死亡。过程评估将采用定性方法进行。定量结果将采用广义线性混合模型进行分析。

伦理和传播

该研究已获得西澳大利亚原住民健康伦理委员会和西澳大利亚大学人类研究伦理委员会的批准。研究结果将发表在同行评议的期刊上,并在科学会议上报告。我们还将为卫生服务部门开发和传播一个全面的 DAMPAA 工具包。该研究的结果将指导未来的预防策略,并概述一个全面的过程评估,这可能对其他原住民健康研究有用,以背景化研究结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/646e/11404219/442d3bfcb068/bmjopen-14-9-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/646e/11404219/d3488b172e3e/bmjopen-14-9-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/646e/11404219/442d3bfcb068/bmjopen-14-9-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/646e/11404219/d3488b172e3e/bmjopen-14-9-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/646e/11404219/442d3bfcb068/bmjopen-14-9-g002.jpg

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本文引用的文献

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Lancet Public Health. 2023 Sep;8(9):e717-e725. doi: 10.1016/S2468-2667(23)00146-9.
2
Co-design of dementia prevention program for Aboriginal Australians (DAMPAA).为澳大利亚原住民设计的痴呆症预防计划(DAMPAA)。
Alzheimers Dement. 2023 Oct;19(10):4564-4571. doi: 10.1002/alz.13032. Epub 2023 Mar 18.
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Validation of the Good Spirit, Good Life quality-of-life tool for older Aboriginal Australians.
验证古迪纳夫-金生活质量工具在老年原住民澳大利亚人中的适用性。
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Barriers and Enablers to Older Indigenous People Engaging in Physical Activity-A Qualitative Systematic Review.老年原住民参与体育活动的障碍与促进因素——一项定性系统综述
J Aging Phys Act. 2022 Apr 1;30(2):340-352. doi: 10.1123/japa.2020-0465. Epub 2021 Aug 18.
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