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HN-SIB-BPI:一种通过单次点击、针对亚部位特定的剂量学计分卡调整的快速计划模型,该模型由用于双侧颈部头颈部治疗的基础模型创建。

HN-SIB-BPI: A single click, sub-site specific, dosimetric scorecard tuned RapidPlan model created from a foundation model for treating head and neck with bilateral neck.

作者信息

Magliari Anthony, Clark Ryan, Rosa Lesley, Beriwal Sushil

机构信息

Varian Medical Systems 3100 Hansen ID, USA.

Varian Medical Systems 3100 Hansen ID, USA.

出版信息

Med Dosim. 2025;50(1):63-69. doi: 10.1016/j.meddos.2024.08.002. Epub 2024 Sep 13.

Abstract

To develop a Knowledge Based Planning (KBP) model for creating quantifiably high quality VMAT treatment plans in a single click for head and neck cases treated Simultaneous Integrated Boost (SIB) with bilateral parotid involvement (BPI) where both parotids are near, abutting or partially overlapping target volume. Eclipse RapidPlan and the publicly available PlanScorecard tool were used to assess existing Head and Neck RapidPlan models on two representative cases. The best performer was used as a foundation model to assist in creating new initial training set doses from previously treated cases. Those initial 27 cases were first replanned using only the selected foundation model, then further improved based on manual replanning, informed by dosimetric scorecard assessment. A new, initial model was trained from those 27 foundation model created cases that had been manually improved. Then, that initial model was used to replan those cases again, resulting in higher scores. Additional cases were also replanned using the initial model along with some manual changes to the optimization objectives to increase the score. This resulted in a total of 66 cases from which the final, released, HN-SIB-BPI was trained. A 27 case subset of the full training set was replanned and rescored at each phase of the process with a 260 total point 3-target scorecard. The average score increased: 210.5 foundation model; 226.96 manually improved plans; 230.1 initial model; 231.7 HN-SIB-BPI. On the same 27 case subset, mean ipsilateral and contralateral parotid dose decreased by 1.05Gy and 1.58Gy respectively from the foundation model to HN-SIB-BP. Eight external cases were created from HN-SIB-BPI with dosimetric scorecard validation on Halcyon (3-PTV:221.38/260; 2-PTV:196.1/228.5) and TrueBeam (3-PTV:222.01/260; 2-PTV:202.24/228.5). A specific clinical intent (ie: max parotid sparing) can be articulated in a comprehensive and precise manner by creating a dosimetric scorecard with individual metrics points assigned to each OAR and target metric reflecting their relative importance. This process improved the KBP model (HN-SIB-BPI) in several quantifiable ways including further sparing of parotid dose. All results and tools in this work are shared publicly.

摘要

为开发一种基于知识的计划(KBP)模型,以便在单次点击中为头颈部病例创建可量化的高质量容积调强放疗(VMAT)治疗计划,这些病例采用同步整合加量(SIB)且双侧腮腺受累(BPI),即双侧腮腺靠近、邻接或部分重叠靶区。使用Eclipse RapidPlan和公开可用的PlanScorecard工具对两个代表性病例的现有头颈部RapidPlan模型进行评估。表现最佳的模型被用作基础模型,以协助根据先前治疗的病例创建新的初始训练集剂量。最初的27个病例首先仅使用选定的基础模型重新计划,然后根据剂量学计分卡评估,在手动重新计划的基础上进一步改进。从经过手动改进的27个基础模型创建病例中训练出一个新的初始模型。然后,使用该初始模型再次对这些病例进行重新计划,从而获得更高的分数。还使用初始模型对其他病例进行重新计划,并对优化目标进行一些手动更改以提高分数。这总共产生了66个病例,从中训练出最终发布的头颈部SIB-BPI模型。在该过程的每个阶段,使用260分的3靶区计分卡对完整训练集的27个病例子集进行重新计划和重新评分。平均分数提高了:基础模型为210.5分;手动改进计划为226.96分;初始模型为230.1分;头颈部SIB-BPI为231.7分。在同一27个病例子集中,从基础模型到头颈部SIB-BP,同侧和对侧腮腺的平均剂量分别降低了1.05Gy和1.58Gy。从具有剂量学计分卡验证的头颈部SIB-BPI创建了8个外部病例,分别在Halcyon(3靶区体积:221.38/260;2靶区体积:196.1/228.5)和TrueBeam(3靶区体积:222.01/260;2靶区体积:202.24/228.5)上进行验证。通过创建一个剂量学计分卡,为每个危及器官(OAR)和靶区指标分配单独的度量点,以反映它们的相对重要性,可以以全面而精确的方式阐明特定的临床意图(即:最大程度地保护腮腺)。该过程以多种可量化的方式改进了KBP模型(头颈部SIB-BPI),包括进一步减少腮腺剂量。这项工作中的所有结果和工具均已公开共享。

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