Delpierre S, Peyrot J, Guillot C, Grimaud C
Arch Int Pharmacodyn Ther. 1985 May;275(1):47-58.
The ventilatory effects of domperidone (DP), a dopamine antagonist that does not cross the blood-brain barrier, were studied on rabbits anaesthetized with pentobarbitone. DP induced hyperventilation (+20%), which was not dose-dependent, without any marked change in arterial blood gases. This effect was abolished by previous transection of both carotid sinus nerves. On an average, steady state hypoxia (PaO2 approximately 45 mmHg for 5 min) doubled ventilation before, and increased itself threefold after DP (0.10 mg kg-1 i.v.). Prazosin (PZ, 0.1 mg kg-1 i.v.), an alpha 1-adrenoceptor antagonist, induced hyperventilation (+16%) but decreased systemic arterial blood pressure. PZ did not modify the ventilatory response to steady state hypoxia. In short, DP has a slight stimulating effect on resting ventilation and potentiates the ventilatory response to steady state hypoxia. This last effect would not depend on additional alpha 1-adrenoceptor antagonism of DP, as PZ does not change the ventilatory response to hypoxia.
多潘立酮（DP）是一种不能穿过血脑屏障的多巴胺拮抗剂，本研究观察了其对戊巴比妥麻醉兔的通气效应。DP可引起通气过度（增加20%），此效应不呈剂量依赖性，且动脉血气无明显变化。预先切断双侧颈动脉窦神经可消除此效应。平均而言，稳态低氧（PaO2约45 mmHg，持续5分钟）使通气在DP（静脉注射0.10 mg/kg）前增加一倍，在注射后增加两倍。哌唑嗪（PZ，静脉注射0.1 mg/kg），一种α1肾上腺素能受体拮抗剂，可引起通气过度（增加16%），但降低体循环动脉血压。PZ不改变对稳态低氧的通气反应。简而言之，DP对静息通气有轻微刺激作用，并增强对稳态低氧的通气反应。后一种效应不依赖于DP额外的α1肾上腺素能受体拮抗作用，因为PZ不改变对低氧的通气反应。
