Wu Zhuo, Zeng Liangtang, Fang Zhou, Yuan Yuan, Zhou Yu, Chen Rufu
School of Medicine, South China University of Technology, Guangzhou, China.
Department of Pancreatic Surgery, Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Int J Cancer. 2025 Feb 1;156(3):566-574. doi: 10.1002/ijc.35184. Epub 2024 Sep 15.
The association between the American Heart Association (AHA) Life's Essential 8 (LE8) and the risk of pancreatic cancer (PC) remains unclear. Our goal was to assess the relationships between LE8, genetic susceptibility, and PC risk. This cohort consisted of 234,102 participants from the UK Biobank. The components of LE8 include diet, nicotine exposure, sleep, physical activity, blood glucose, body mass index, blood lipids, and blood pressure. LE8 is classified into three categories: low cardiovascular health (CVH), moderate CVH, and high CVH. Measurements were made using Cox proportional risk models to estimate impact of associations between LE8, genetic susceptibility, and incidence of PC in participants. Compared to participants with low LE8 scores, those with moderate and high LE8 scores had a 53% (HR, 0.47; 95% CI, 0.39-0.57) and 70% (HR, 0.30; 95% CI, 0.22-0.41) lower risk of developing PC, respectively. Interestingly, among individuals with high genetic risk, high LE8 scores were associated with greater benefits (HR, 0.24; 95% CI, 0.15-0.40), whereas the protective effect was weaker among those with low genetic risk (HR, 0.40; 95% CI, 0.21-0.75). Participants with a high LE8 score and a low polygenic risk score (PRS) had the lowest risk of PC (HR, 0.19; 95% CI: 0.11-0.33). Furthermore, we observed a significant additive interaction between LE8 and PRS. A higher LE8 score is associated with a lower risk of PC, especially for participants with a high PRS. These findings have important implications for participants most genetically predisposed to PC and for targeted strategies for PC prevention.
美国心脏协会（AHA）的生命基本八大要素（LE8）与胰腺癌（PC）风险之间的关联尚不清楚。我们的目标是评估LE8、遗传易感性和PC风险之间的关系。该队列由来自英国生物银行的234,102名参与者组成。LE8的组成部分包括饮食、尼古丁暴露、睡眠、身体活动、血糖、体重指数、血脂和血压。LE8分为三类：低心血管健康（CVH）、中度CVH和高CVH。使用Cox比例风险模型进行测量，以估计LE8、遗传易感性与参与者中PC发病率之间关联的影响。与LE8得分低的参与者相比，LE8得分中等和高的参与者患PC的风险分别低53%（HR，0.47；95%CI，0.39 - 0.57）和70%（HR，0.30；95%CI，0.22 - 0.41）。有趣的是，在遗传风险高的个体中，LE8得分高与更大的益处相关（HR，0.24；95%CI，0.15 - 0.40），而在遗传风险低的个体中，保护作用较弱（HR，0.40；95%CI，0.21 - 0.75）。LE8得分高且多基因风险评分（PRS）低的参与者患PC的风险最低（HR，0.19；95%CI：0.11 - 0.33）。此外，我们观察到LE8和PRS之间存在显著的相加交互作用。较高的LE8得分与较低的PC风险相关，尤其是对于PRS高的参与者。这些发现对于PC遗传易感性最高的参与者以及PC预防的靶向策略具有重要意义。
