尼卡地平对正常志愿者垂体激素释放的影响。
The effect of nicardipine on pituitary hormone release in normal volunteers.
作者信息
Isles T E, Baty J, Dow R J
出版信息
Br J Clin Pharmacol. 1985;20 Suppl 1(Suppl 1):84S-87S. doi: 10.1111/j.1365-2125.1985.tb05147.x.
In a double-blind, placebo-controlled, randomised, cross-over study of six healthy male subjects, the effect of nicardipine (5 mg h-1 for 3 h) on basal and stimulated pituitary hormone release was examined. Statistically significant differences between nicardipine and placebo were seen occasionally for follicle-stimulating hormone, luteinising hormone and prolactin, but not for thyroid-stimulating hormone. These differences were always within the between-batch coefficient of variation of the assay. The overall differences in both basal and stimulated results for all four pituitary hormones were not statistically significantly different. It is concluded, therefore, that nicardipine has no significant effect on either basal or stimulated pituitary hormone release in healthy male subjects.
在一项针对6名健康男性受试者的双盲、安慰剂对照、随机交叉研究中，研究了尼卡地平（5毫克/小时，持续3小时）对基础和刺激状态下垂体激素释放的影响。尼卡地平和安慰剂之间在促卵泡激素、促黄体生成素和催乳素方面偶尔出现统计学上的显著差异，但促甲状腺激素方面未出现差异。这些差异始终在检测的批次间变异系数范围内。所有四种垂体激素的基础和刺激结果的总体差异在统计学上无显著差异。因此得出结论，尼卡地平对健康男性受试者基础或刺激状态下的垂体激素释放均无显著影响。
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