Shen Qingqing, Zhang Qing, Liu Yunxiao, Cui Yingao, Shang Jingwen, Yuan Xiaoping, Geng Feng, Sun Liang, Liu Zhiwei, Yang Rongchun, Zhang Kai, Liu Huanzhong
Department of Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Psychol Res Behav Manag. 2024 Sep 9;17:3121-3131. doi: 10.2147/PRBM.S473074. eCollection 2024.
The purpose of this study was to further explore the association of pain intensity and sensitivity with suicidal ideation in adolescents with depressive disorder by comparing the differences in pain intensity and sensitivity between adolescent patients with depressive disorders and healthy controls.
A consecutive enrollment method was used to select 158 adolescent patients with depressive disorders from three hospitals in Anhui Province as the MDD group, and 47 healthy adolescents were recruited as the Control group. The subjects' suicidal ideation was assessed using the Positive and Negative Suicide Ideation scale (PANSI), and the intensity of somatic pain was assessed using the Numerical Rating Scale-11 (NRS-11). Subjects were assessed for forearm and tibial pain sensitivity using a hand-held pressure pain instrument, and experimental pain sensitivity measures included pressure pain threshold (PPT) and pressure pain tolerance (PTO). Differences in pain intensity and sensitivity between the MDD group and the Control group were compared, and the association of pain intensity and sensitivity with suicidal ideation was analyzed.
The incidence of physical pain in adolescent depressive disorder was higher at 88.6%, which was significantly higher than the Control group (<0.001), and the pain intensity in the MDD group (3.77±2.48) was significantly higher than the Control group (0.617±0.99) (P <0.001).The Pain tolerance was significantly higher in the MDD group (forearm 105.37 ± 41.46; tibia 121.29 ± 41.60) than in the Control group (forearm 91.92 ± 37.62; tibia 105.47 ± 35.52) ( < 0.05).Linear regression analysis showed that the greater the pain intensity and pain tolerance, the higher the total PANSI score.Binary logistic regression showed that pain intensity was an influencing factor for suicidal ideation.
Adolescents with depressive disorders have higher pain intensity and lower pain sensitivity than healthy adolescents. Increased pain intensity and pain tolerance were positively correlated with suicidal ideation.
本研究旨在通过比较青少年抑郁症患者与健康对照者在疼痛强度和敏感性方面的差异，进一步探讨青少年抑郁症患者疼痛强度和敏感性与自杀意念之间的关联。
采用连续入组的方法，从安徽省三家医院选取158例青少年抑郁症患者作为重度抑郁症（MDD）组，招募47例健康青少年作为对照组。使用正负性自杀意念量表（PANSI）评估受试者的自杀意念，使用数字评定量表-11（NRS-11）评估躯体疼痛强度。使用手持式压力疼痛仪评估受试者前臂和胫骨的疼痛敏感性，实验性疼痛敏感性测量包括压力疼痛阈值（PPT）和压力疼痛耐受度（PTO）。比较MDD组和对照组在疼痛强度和敏感性方面的差异，并分析疼痛强度和敏感性与自杀意念的关联。
青少年抑郁症患者躯体疼痛发生率较高，为88.6%，显著高于对照组（<0.001），MDD组的疼痛强度（3.77±2.48）显著高于对照组（0.617±0.99）（P<0.001）。MDD组的疼痛耐受度（前臂105.37±41.46；胫骨121.29±41.60）显著高于对照组（前臂91.92±37.62；胫骨105.47±35.52）（<0.05）。线性回归分析显示，疼痛强度和疼痛耐受度越高，PANSI总分越高。二元逻辑回归显示，疼痛强度是自杀意念的一个影响因素。
与健康青少年相比，青少年抑郁症患者的疼痛强度更高，疼痛敏感性更低。疼痛强度增加和疼痛耐受度与自杀意念呈正相关。
