Simeone Timothy, Simeone Kristina
Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE, USA.
Epilepsy Curr. 2024 Jan 10;24(2):117-122. doi: 10.1177/15357597231216916. eCollection 2024 Mar-Apr.
The integration of metabolic therapeutics in the available clinical armory is becoming more commonplace in health care as our understanding about the dependence of disease on metabolism continues to deepen and evolve. In the epilepsy field, we often think about the ketogenic diet (KD, high fat: carbohydrate ratio) in terms of its anti-seizure efficacy. The aim of this article is to review what we've learned from preclinical studies about the KD's more unconventional effects, including its neuroprotective effects, anti-epileptogenic and disease-modifying effects, and how the KD influences comorbidities associated with epilepsy. As time moves us into the future and metabolic therapies become more common place, the effects of the KD considered herein, may end up being referred to as .
随着我们对疾病与代谢之间依赖关系的理解不断深入和发展，代谢疗法在现有临床手段中的整合在医疗保健领域正变得越来越普遍。在癫痫领域，我们通常从生酮饮食（KD，高脂肪：碳水化合物比例）的抗癫痫疗效方面来考虑它。本文的目的是回顾我们从临床前研究中学到的关于生酮饮食的更非传统的作用，包括其神经保护作用、抗癫痫发生和疾病修饰作用，以及生酮饮食如何影响与癫痫相关的合并症。随着时间推移，我们迈向未来，代谢疗法变得更加普遍，本文所考虑的生酮饮食的作用最终可能会被称为……
