• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Human sulfotransferase physiological role and the impact of genetic polymorphism on enzyme activity and pathological conditions.人类磺基转移酶的生理作用以及基因多态性对酶活性和病理状况的影响。
Front Genet. 2024 Aug 30;15:1464243. doi: 10.3389/fgene.2024.1464243. eCollection 2024.
2
The role of genetic polymorphisms in the sulfation of pregnenolone by human cytosolic sulfotransferase SULT2B1a.人类胞质硫酸转移酶SULT2B1a对孕烯醇酮硫酸化中基因多态性的作用。
Res Sq. 2023 Oct 27:rs.3.rs-3471389. doi: 10.21203/rs.3.rs-3471389/v1.
3
Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase.人类羟基类固醇硫酸转移酶SULT2B1亚型的突变分析表明，SULT2B1基因的外显子1B产生胆固醇硫酸转移酶，而外显子1A产生孕烯醇酮硫酸转移酶。
J Biol Chem. 2002 Sep 27;277(39):36161-6. doi: 10.1074/jbc.M207165200. Epub 2002 Jul 26.
4
The role of genetic polymorphisms in the sulfation of pregnenolone by human cytosolic sulfotransferase SULT2B1a.遗传多态性在人胞质磺基转移酶 SULT2B1a 对孕烯醇酮磺化中的作用。
Sci Rep. 2024 Apr 5;14(1):8050. doi: 10.1038/s41598-024-56303-y.
5
Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b).人3β-羟基类固醇磺基转移酶（SULT2B1a和SULT2B1b）的表达与特性分析
J Steroid Biochem Mol Biol. 2001 Jun;77(4-5):261-9. doi: 10.1016/s0960-0760(01)00064-4.
6
Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: gene sequence variation and functional genomics.人羟基类固醇硫酸转移酶SULT2B1药物基因组学：基因序列变异与功能基因组学
J Pharmacol Exp Ther. 2007 Aug;322(2):529-40. doi: 10.1124/jpet.107.122895. Epub 2007 May 11.
7
Cloning, characterization and tissue expression of rat SULT2B1a and SULT2B1b steroid/sterol sulfotransferase isoforms: divergence of the rat SULT2B1 gene structure from orthologous human and mouse genes.大鼠SULT2B1a和SULT2B1b类固醇/甾醇磺基转移酶亚型的克隆、特性分析及组织表达：大鼠SULT2B1基因结构与直系同源人类和小鼠基因的差异
Gene. 2006 Feb 15;367:66-73. doi: 10.1016/j.gene.2005.09.009. Epub 2005 Dec 20.
8
Effect of SULT2B1 genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by SULT2B1b allozymes.SULT2B1 基因多态性对 SULT2B1b 同工酶催化去氢表雄酮和孕烯醇酮磺化的影响。
Mol Cell Endocrinol. 2019 Oct 1;496:110535. doi: 10.1016/j.mce.2019.110535. Epub 2019 Aug 7.
9
Biochemical characterization and tissue distribution of human SULT2B1.人磺基转移酶2B1（SULT2B1）的生化特性及组织分布
Biochem Biophys Res Commun. 2001 Oct 19;288(1):280-9. doi: 10.1006/bbrc.2001.5746.
10
Identification and immunohistochemical localization of Sulfotransferase 2B1b (SULT2B1b) in human lung.人肺中磺基转移酶2B1b（SULT2B1b）的鉴定及免疫组化定位
Biochim Biophys Acta. 2005 Jun 20;1724(1-2):119-26. doi: 10.1016/j.bbagen.2005.03.018. Epub 2005 Apr 12.

引用本文的文献

1
Transcriptome Analysis Reveals Differential Gene Regulation in Ovarian Tissues of Anabas testudineus (Bloch, 1792) in Response to Insecticide, Monocrotophos.转录组分析揭示了龟壳攀鲈（Anabas testudineus，布洛赫，1792年）卵巢组织对杀虫剂久效磷的差异基因调控。
Mar Biotechnol (NY). 2025 Mar 18;27(2):66. doi: 10.1007/s10126-025-10443-y.

本文引用的文献

1
Liver-specific Lxr inhibition represses reverse cholesterol transport in cholesterol-fed mice.肝特异性 Lxr 抑制可抑制胆固醇喂养小鼠的胆固醇逆向转运。
Atherosclerosis. 2024 Oct;397:117578. doi: 10.1016/j.atherosclerosis.2024.117578. Epub 2024 May 12.
2
Knockdown of sulfotransferase 2B1 suppresses cell migration, invasion and promotes apoptosis in ovarian carcinoma cells via targeting annexin A9.通过靶向膜联蛋白 A9，磺基转移酶 2B1 的敲低抑制卵巢癌细胞的迁移、侵袭并促进细胞凋亡。
J Obstet Gynaecol Res. 2024 Aug;50(8):1334-1344. doi: 10.1111/jog.15969. Epub 2024 May 22.
3
Sulfotransferase SULT2B1 facilitates colon cancer metastasis by promoting SCD1-mediated lipid metabolism.磺基转移酶 SULT2B1 通过促进 SCD1 介导的脂质代谢促进结肠癌转移。
Clin Transl Med. 2024 Feb;14(2):e1587. doi: 10.1002/ctm2.1587.
4
Reducing SULT2B1 promotes the interaction of LncRNAgga3-204 with SMAD4 to inhibit the macrophage inflammatory response and delay atherosclerosis progression.降低 SULT2B1 表达可促进 LncRNAgga3-204 与 SMAD4 相互作用，从而抑制巨噬细胞炎症反应，延缓动脉粥样硬化进展。
Transl Res. 2024 Jun;268:13-27. doi: 10.1016/j.trsl.2024.01.004. Epub 2024 Jan 28.
5
IκB kinase β (IKKβ): Structure, transduction mechanism, biological function, and discovery of its inhibitors.IKKβ（IκB 激酶 β）：结构、转导机制、生物学功能及其抑制剂的发现。
Int J Biol Sci. 2023 Aug 6;19(13):4181-4203. doi: 10.7150/ijbs.85158. eCollection 2023.
6
The Immunosuppressive Potential of Cholesterol Sulfate Through T Cell Microvilli Disruption.胆固醇硫酸酯通过破坏T细胞微绒毛发挥免疫抑制作用。
Immune Netw. 2023 Jun 15;23(3):e29. doi: 10.4110/in.2023.23.e29. eCollection 2023 Jun.
7
A novel extrachromosomal circular DNA related genes signature for overall survival prediction in patients with ovarian cancer.一种新型的与染色体外环状 DNA 相关的基因特征，可用于预测卵巢癌患者的总生存期。
BMC Med Genomics. 2023 Jun 19;16(1):140. doi: 10.1186/s12920-023-01576-x.
8
Cholesterol sulfate inhibits osteoclast differentiation and survival by regulating the AMPK-Sirt1-NF-κB pathway.硫酸胆固醇通过调节 AMPK-Sirt1-NF-κB 通路抑制破骨细胞分化和存活。
J Cell Physiol. 2023 Sep;238(9):2063-2075. doi: 10.1002/jcp.31064. Epub 2023 Jun 19.
9
Cholesterol sulfate limits neutrophil recruitment and gut inflammation during mucosal injury.硫酸胆固醇可限制黏膜损伤时中性粒细胞的募集和肠道炎症。
Front Immunol. 2023 Mar 17;14:1131146. doi: 10.3389/fimmu.2023.1131146. eCollection 2023.
10
Overcoming T-cell exhaustion: New therapeutic targets in HCC immunotherapy.克服T细胞耗竭：肝癌免疫治疗中的新治疗靶点。
Hepatology. 2023 Oct 1;78(4):1009-1011. doi: 10.1097/HEP.0000000000000039. Epub 2023 Jan 3.

人类磺基转移酶的生理作用以及基因多态性对酶活性和病理状况的影响。

Human sulfotransferase physiological role and the impact of genetic polymorphism on enzyme activity and pathological conditions.

作者信息

Alherz Fatemah A

机构信息

Department of Pharmaceutical Science, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.

出版信息

Front Genet. 2024 Aug 30;15:1464243. doi: 10.3389/fgene.2024.1464243. eCollection 2024.

DOI:10.3389/fgene.2024.1464243
PMID:39280099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11392796/
Abstract

Human gene is responsible for expressing SULT2B1a and SULT2B1b enzymes, which are phase II metabolizing enzymes known as pregnenolone and cholesterol sulfotransferase (SULT), respectively. They are expressed in several tissues and contribute to steroids and hydroxysteroids homeostasis. Genetic variation of the is reported to be associated with various pathological conditions, including autosomal recessive ichthyosis, cardiovascular disease, and different types of cancers. Understanding the pathological impact of genetic polymorphisms in the human body is crucial to incorporating these findings in evaluating clinical conditions or improving therapeutic efficacy. Therefore, this paper summarized the most relevant reported studies concerning expression, tissue distribution, substrates, and reported genetic polymorphisms and their mechanisms in enzyme activity and pathological conditions.

摘要

人类基因负责表达SULT2B1a和SULT2B1b酶，它们是II相代谢酶，分别称为孕烯醇酮和胆固醇磺基转移酶（SULT）。它们在多种组织中表达，并有助于维持类固醇和羟基类固醇的体内平衡。据报道，该基因的遗传变异与多种病理状况有关，包括常染色体隐性鱼鳞病、心血管疾病和不同类型的癌症。了解该基因多态性在人体中的病理影响对于将这些发现纳入临床状况评估或提高治疗效果至关重要。因此，本文总结了有关该基因表达、组织分布、底物以及已报道的基因多态性及其在酶活性和病理状况中的机制的最相关研究。