Li Jiafeng, Li Yifan, Shang Xiushuai, Xu Sheng, Zhang Zhen, Xu Sanzhong, Wang Xuanwei, Shen Miaoda
Department of Orthopedics, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou, China.
Department of Orthopedics, People's Hospital of Changshan County, Quzhou, China.
Mater Today Bio. 2024 Aug 20;28:101202. doi: 10.1016/j.mtbio.2024.101202. eCollection 2024 Oct.
Osteoarthritis (OA) is one of the most prevalent joint diseases and severely affects the quality of life in the elderly population. However, there are currently no effective prevention or treatment options for OA. Oxidative stress and pyroptosis play significant roles in the development and progression of OA. To address this issue, we have developed a novel therapeutic approach for OA that targets oxidative stress and pyroptosis. We synthesized tetrahedral framework nucleic acid (tFNAs) to form framework nucleic acid complexes (TNCs), which facilitate the delivery of the naturally occurring polymethoxyflavonoid nobiletin (Nob) to chondrocytes. TNC has demonstrated favorable bioavailability, stability, and biosafety for delivering Nob. Both and experiments have shown that TNC can alleviate OA and protect articular cartilage from damage by eliminating oxidative stress, inhibiting pyroptosis, and restoring the extracellular matrix anabolic metabolism of chondrocytes. These findings suggest that TNC has significant potential in the treatment of OA and cartilage injury.
骨关节炎（OA）是最常见的关节疾病之一，严重影响老年人群的生活质量。然而，目前尚无针对OA的有效预防或治疗方法。氧化应激和细胞焦亡在OA的发生和发展中起重要作用。为了解决这个问题，我们开发了一种针对OA的新型治疗方法，该方法靶向氧化应激和细胞焦亡。我们合成了四面体框架核酸（tFNA）以形成框架核酸复合物（TNC），其有助于将天然存在的多甲氧基黄酮诺米林（Nob）递送至软骨细胞。TNC已证明在递送Nob方面具有良好的生物利用度、稳定性和生物安全性。体内和体外实验均表明，TNC可通过消除氧化应激、抑制细胞焦亡和恢复软骨细胞的细胞外基质合成代谢来减轻OA并保护关节软骨免受损伤。这些发现表明，TNC在OA和软骨损伤的治疗中具有巨大潜力。
