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费尔蒂综合征伴白色念珠菌肺脓肿且无关节炎:一例报告

Felty Syndrome Presented With Candida albicans Lung Abscess Without Arthritis: A Case Report.

作者信息

Ahmed Mohammed, Abdelrahim Mohanad, Mohammed Mortada, Cyril James

机构信息

Cardiology, Aintree University Hospitals NHS Foundation Trust, Liverpool, GBR.

Internal Medicine, St Helens and Knowsley Teaching Hospitals NHS Trust, Liverpool, GBR.

出版信息

Cureus. 2024 Aug 16;16(8):e66989. doi: 10.7759/cureus.66989. eCollection 2024 Aug.

Abstract

Felty syndrome (FS) is a late manifestation of severe active rheumatoid arthritis (RA). A high index of suspicion or FS is needed in patients who present with neutropaenia and splenomegaly with no initial or obvious identifiable cause. We present the case of a 52-year-old who presented with a one-week history of haemoptysis, fever, and night sweats. The patient was hypotensive, tachycardia, and febrile (38 °C). On examination, bilateral crackles and reduced air entry were identified on the right basal and middle zones. The patient was diagnosed with RA two years prior to this presentation and was not on a disease-modifying antirheumatic drug (DMARD). Haematology showed high inflammatory markers and pancytopenia. Chest X-ray showed a right upper lobe abscess. CT-thorax, abdomen, and pelvis confirmed lung abscesses and hepatosplenomegaly. Candida albicans was detected on the broncho-alveolar lavage. He responded well to antifungal medication and corticosteroids with normalisation of the pancytopenia and inflammatory markers and reduction of the spleen size. This case report details the unusual and early presentation of FS in a patient newly diagnosed with RA and who had no active arthritis. We wish to emphasize the importance of a high index of suspicion in patients with RA regardless of the length of their illness.

摘要

费尔蒂综合征(FS)是重度活动性类风湿关节炎(RA)的晚期表现。对于出现中性粒细胞减少和脾肿大且无初始或明显可识别病因的患者,需要高度怀疑患有FS。我们报告一例52岁患者,其有咯血、发热和盗汗一周的病史。患者血压低、心动过速且发热(38℃)。检查发现右肺基底和中叶区域有双侧湿啰音且呼吸音减弱。该患者在此次就诊前两年被诊断为RA,未服用改善病情抗风湿药物(DMARD)。血液学检查显示炎症指标升高和全血细胞减少。胸部X线显示右上叶脓肿。胸部、腹部和骨盆CT证实有肺脓肿和肝脾肿大。支气管肺泡灌洗检测到白色念珠菌。他对抗真菌药物和皮质类固醇反应良好,全血细胞减少和炎症指标恢复正常,脾脏大小缩小。本病例报告详细描述了FS在一名新诊断为RA且无活动性关节炎患者中的不寻常早期表现。我们希望强调,无论病程长短,对RA患者保持高度怀疑的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ced/11402277/5fd59be2edec/cureus-0016-00000066989-i01.jpg

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