Alrashidi Ahlam S, Feraih Aljaghwani Lujain, Saleh AlMohimeed Raghad
Department of Obstetrics and Gynecology, Maternity and Children Hospital, Buraydah, SAU.
Cureus. 2024 Aug 16;16(8):e67028. doi: 10.7759/cureus.67028. eCollection 2024 Aug.
Assisted reproductive technologies (ART) have improved infertility treatment but reproductive outcomes remain challenging. Nutrient supplementation is being explored to enhance pregnancy rates, increase live birth rates, and reduce miscarriage rates in females undergoing ART. Nutrients like folic acid, omega-3 fatty acids, and antioxidants have shown potential benefits, yet conflicting results exist. Live birth rates may also be influenced by nutrient supplementation, with coenzyme Q10 and vitamin D showing promise. Miscarriage rates may be reduced with nutrients such as vitamin D, omega-3 fatty acids, and antioxidants, although more research is needed for definitive conclusions. Scientific and medical literature databases such as Cochrane Library, PubMed, and Web of Science were queried to identify relevant English publications adhering to predetermined inclusion and exclusion criteria. Various reproductive metrics, encompassing biochemical pregnancy rate, clinical pregnancy rate, ongoing pregnancy rate, implantation rate, live birth rates, and miscarriage rates, were assessed as clinical endpoints. The study population included 996 female subjects receiving ART. Two studies performed investigations on subjects diagnosed with unexplained infertility, two studies specifically included polycystic ovary syndrome patients, and five studies did not provide any specific information on the type of infertility or subfertility. All studies reported on the clinical/ongoing pregnancy rate, among which four included studies observed a significantly higher rate. Out of the four studies that reported on implantation rates, three found significantly higher rates in treatment groups. Out of the three studies that reported on biochemical pregnancy rates, two studies found significantly higher rates in treatment groups. With respect to the clinical outcomes that were studied in this analysis, variable effects of nutritional supplementation on reproductive parameters were observed. Some studies reported significantly higher rates of clinical/ongoing pregnancy, implantation, biochemical pregnancy, and live birth, while no significant difference was found in miscarriage rates.
辅助生殖技术（ART）改善了不孕症治疗，但生殖结局仍然具有挑战性。人们正在探索营养补充剂，以提高接受ART的女性的妊娠率、提高活产率并降低流产率。叶酸、ω-3脂肪酸和抗氧化剂等营养素已显示出潜在益处，但结果存在矛盾。活产率也可能受营养补充剂影响，辅酶Q10和维生素D显示出一定前景。维生素D、ω-3脂肪酸和抗氧化剂等营养素可能降低流产率，不过还需要更多研究才能得出明确结论。查询了Cochrane图书馆、PubMed和科学网等科学与医学文献数据库，以识别符合预定纳入和排除标准的相关英文出版物。评估了包括生化妊娠率、临床妊娠率、持续妊娠率、着床率、活产率和流产率在内的各种生殖指标作为临床终点。研究人群包括996名接受ART的女性受试者。两项研究对诊断为不明原因不孕症的受试者进行了调查，两项研究专门纳入了多囊卵巢综合征患者，五项研究未提供关于不孕症或生育力低下类型的任何具体信息。所有研究都报告了临床/持续妊娠率，其中四项纳入研究观察到该率显著更高。在报告着床率的四项研究中，三项发现治疗组的着床率显著更高。在报告生化妊娠率的三项研究中，两项研究发现治疗组的生化妊娠率显著更高。关于本分析中研究的临床结局，观察到营养补充剂对生殖参数的影响存在差异。一些研究报告临床/持续妊娠、着床、生化妊娠和活产率显著更高，而流产率未发现显著差异。
