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本地膝关节中路邓葡萄球菌败血症性关节炎的迁延病程

Protracted Course of Staphylococcus lugdunensis Septic Arthritis in Native Knee Joint.

作者信息

Howson Sofia, Ma Sara L, Schmidt Jennifer, Bisht Aakash, Chopra Teena

机构信息

Department of Internal Medicine, Wayne State University School of Medicine, Detroit, USA.

Department of Internal Medicine, Wayne State University Detroit Medical Center, Detroit, USA.

出版信息

Cureus. 2024 Aug 14;16(8):e66848. doi: 10.7759/cureus.66848. eCollection 2024 Aug.

DOI:10.7759/cureus.66848
PMID:39280560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11395931/
Abstract

is a coagulase-negative bacteria of the Staphylococcus family. It is a highly invasive organism with similar virulence to . It is commonly associated with bacteremia and infections of the skin, soft tissues, joints, and bones. Those with indwelling medical devices are at the highest risk of infection due to biofilm formation. Instances of native joint infections are exceedingly rare. We describe a case of a 72-year-old female with multiple comorbidities presenting with native right knee joint septic arthritis from . Due to treatment noncompliance secondary to latent social determinants of health, she faced a complicated and protracted clinical course that was treated with inpatient intravenous antibiotics and outpatient oral doxycycline. Few cases of native joint infections with have been documented, and to our knowledge, the impact of treatment noncompliance on the sequelae of septic arthritis with this organism has not been reported. Socioeconomic factors and comorbidities have been shown to increase a patient's risk for an extended joint infection with

摘要

是葡萄球菌属的一种凝固酶阴性细菌。它是一种具有高度侵袭性的微生物,毒力与[具体细菌名称未给出]相似。它通常与菌血症以及皮肤、软组织、关节和骨骼感染有关。因生物膜形成,植入医疗设备的人感染风险最高。原发性关节感染的病例极为罕见。我们描述了一例72岁患有多种合并症的女性,因[具体细菌名称未给出]出现右膝原发性化脓性关节炎。由于潜在的健康社会决定因素导致治疗依从性差,她面临复杂且漫长的临床病程,接受了住院静脉用抗生素和门诊口服多西环素治疗。记录在案的原发性关节感染病例很少,据我们所知,治疗依从性差对这种微生物引起的化脓性关节炎后遗症的影响尚未见报道。社会经济因素和合并症已被证明会增加患者发生[具体细菌名称未给出]所致关节感染延长的风险

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本文引用的文献

1
Bloodstream Infection Due to Coagulase-Negative Staphylococci: Impact of Species on Prevalence of Infective Endocarditis.凝固酶阴性葡萄球菌引起的血流感染:菌种对感染性心内膜炎患病率的影响。
Antibiotics (Basel). 2023 Sep 18;12(9):1453. doi: 10.3390/antibiotics12091453.
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High-Grade Bacteremia in a Patient on Home Hemodialysis.接受家庭血液透析患者的重症菌血症
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Characteristics and outcomes in adult patients with Staphylococcus lugdunensis bacteremia compared to patients with Staphylococcus epidermidis and Staphylococcus aureus bacteremia: a retrospective study in a 16-year period at the university hospital, Japan.
与表皮葡萄球菌和金黄色葡萄球菌菌血症患者相比,凝固酶阴性葡萄球菌菌血症成人患者的特征和结局:日本一所大学医院 16 年回顾性研究。
BMC Infect Dis. 2023 May 1;23(1):269. doi: 10.1186/s12879-023-08233-9.
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The Impact of Social Determinants of Health on Medication Adherence: a Systematic Review and Meta-analysis.社会健康决定因素对药物依从性的影响:系统评价和荟萃分析。
J Gen Intern Med. 2021 May;36(5):1359-1370. doi: 10.1007/s11606-020-06447-0. Epub 2021 Jan 29.
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Staphylococcus lugdunensis: a Skin Commensal with Invasive Pathogenic Potential.路邓葡萄球菌:一种具有侵袭性致病潜能的皮肤共生菌。
Clin Microbiol Rev. 2020 Dec 23;34(2). doi: 10.1128/CMR.00205-20. Print 2021 Mar 17.
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Staphylococcus lugdunensis: Review of Epidemiology, Complications, and Treatment.路邓葡萄球菌:流行病学、并发症及治疗综述
Cureus. 2020 Jun 24;12(6):e8801. doi: 10.7759/cureus.8801.
7
Septic Arthritis following Arthroscopic Anterior Cruciate Ligament Reconstruction.关节镜下前交叉韧带重建术后的化脓性关节炎
Case Rep Orthop. 2020 Jan 20;2020:2813134. doi: 10.1155/2020/2813134. eCollection 2020.
8
Septic arthritis of native hip joint by Staphylococcus lugdunensis: a case report.由路邓葡萄球菌引起的原发性髋关节化脓性关节炎:一例报告。
Rev Soc Bras Med Trop. 2018 Jul-Aug;51(4):554-556. doi: 10.1590/0037-8682-0169-2017.
9
Poverty, Transportation Access, and Medication Nonadherence.贫困、交通可达性与药物不依从。
Pediatrics. 2018 Apr;141(4). doi: 10.1542/peds.2017-3402. Epub 2018 Mar 16.
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Case Rep Infect Dis. 2017;2017:8903907. doi: 10.1155/2017/8903907. Epub 2017 Dec 28.