Food Additives' Impact on Gut Microbiota and Metabolic Syndrome: A Systematic Review.

The human gut microbiota (GM) might play a significant role in the development or remission of metabolic syndrome (MetS) and associated disorders. Contributing factors include diets rich in unhealthy, processed foods that contain preservatives, emulsifiers, and stabilizers. Diet influences the GM's composition, diversity, and species richness in a time-dependent manner. Food additives can alter the GM and contribute to the pathophysiology of MetS by disrupting the intestinal barrier and inducing low-grade systemic inflammation. Our systematic review aims to clarify the relationships among food additives, GM, and MetS. We summarize current knowledge on how food additives interact with GM and the pathogenic role of the microbiota in the development of MetS, including obesity and type 2 diabetes. This review also discusses how disturbances in GM caused by stabilizers and emulsifiers may link to MetS, highlighting the impact of this condition on the development of diabetes and obesity. Furthermore, this review seeks a detailed explanation of how dietary choices related to GM dysbiosis may contribute to MetS. However, more comprehensive and well-designed in vitro, animal, and clinical studies are needed for a better understanding, as research on the role of GM in MetS is still emerging.