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经皮左心室辅助装置救治嗜铬细胞瘤继发儿茶酚胺诱导性心肌病:Impella CP在儿科患者中的新应用

Catecholamine-Induced Cardiomyopathy Secondary to Pheochromocytoma Rescued With Percutaneous Left Ventricular Assist Device: Novel Application of the Impella CP in a Pediatric Patient.

作者信息

Zumwalt Christopher M, Roybal Jessica, Crittendon Ivory, Lucas Victor S, Wells Dennis A

机构信息

Department of Surgery, Ochsner Clinic Foundation, New Orleans, LA.

Division of Pediatric General Surgery, Ochsner Children's Hospital, New Orleans, LA.

出版信息

Ochsner J. 2024 Fall;24(3):229-232. doi: 10.31486/toj.24.0028.

Abstract

Catecholamine-induced cardiomyopathy is an uncommon complication of pheochromocytoma. Pheochromocytoma is a rare tumor that predominantly occurs in adults, making catecholamine-induced cardiomyopathy secondary to pheochromocytoma in children an exceedingly rare presentation. Treatment typically consists of medical management followed by surgical resection. Mechanical support, typically salvage therapy with extracorporeal membrane oxygenation, has been used in adult patients with cardiogenic shock and after cardiac arrest, but to our knowledge, the use of mechanical support has not been described in pediatric patients. A 16-year-old female presented with cardiogenic shock resulting from catecholamine-induced cardiomyopathy secondary to pheochromocytoma. She was treated with a percutaneous left ventricular assist device to allow myocardial recovery while medical therapy was optimized. Given the early initiation, the patient's myocardial recovery was prompt, and only 3 days of device support were required. She was discharged in good condition and subsequently underwent uncomplicated laparoscopic resection of the tumor a few weeks later. In pediatric patients with catecholamine-induced cardiomyopathy secondary to pheochromocytoma, aggressive measures of support-including mechanical support and infrequently used options such as percutaneous left ventricular assist devices-should be considered early in treatment to maintain adequate cardiac output, avoid cardiac arrest, and allow for prompt myocardial recovery.

摘要

儿茶酚胺诱导的心肌病是嗜铬细胞瘤一种罕见的并发症。嗜铬细胞瘤是一种主要发生于成年人的罕见肿瘤,使得继发于嗜铬细胞瘤的儿茶酚胺诱导的心肌病在儿童中极为罕见。治疗通常包括药物治疗,随后进行手术切除。机械支持,通常是体外膜肺氧合的挽救治疗,已用于患有心源性休克的成年患者及心脏骤停后,但据我们所知,尚未有关于在儿科患者中使用机械支持的描述。一名16岁女性因继发于嗜铬细胞瘤的儿茶酚胺诱导的心肌病而出现心源性休克。她接受了经皮左心室辅助装置治疗,以便在优化药物治疗的同时使心肌恢复。鉴于早期启动,患者心肌恢复迅速,仅需3天的装置支持。她出院时情况良好,几周后随后顺利接受了肿瘤的腹腔镜切除术。在继发于嗜铬细胞瘤的儿茶酚胺诱导的心肌病的儿科患者中,应在治疗早期考虑积极的支持措施,包括机械支持以及如经皮左心室辅助装置等不常用的选择,以维持足够的心输出量,避免心脏骤停,并使心肌迅速恢复。

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Pheochromocytoma-induced cardiogenic shock.嗜铬细胞瘤性心原性休克。
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本文引用的文献

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Catecholamine-induced Myocarditis in a Child with Pheochromocytoma.儿茶酚胺诱导的嗜铬细胞瘤患儿心肌炎。
J Clin Res Pediatr Endocrinol. 2020 Jun 3;12(2):202-205. doi: 10.4274/jcrpe.galenos.2019.2019.0045. Epub 2019 Jun 18.
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Life-threatening events in patients with pheochromocytoma.患者发生嗜铬细胞瘤危象。
Eur J Endocrinol. 2015 Dec;173(6):757-64. doi: 10.1530/EJE-15-0483. Epub 2015 Sep 7.

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