Cutting-Edge Methodological Guidance for Authors in Conducting the Systematic Review and Meta-Analysis.

The landscape of systematic reviews and meta-analyses (SRMA) in biomedicine has expanded exponentially, driven by the growing demand for evidence-based healthcare decision-making. However, the rapid increase of SRMAs has often outpaced the development of rigorous methodological standards, resulting in variability in quality and potentially limiting their effectiveness in informing healthcare practices. This gap highlights the critical need for advanced methodological guidance to enhance the quality and impact of SRMAs. Our contribution aims to provide comprehensive methodological direction for authors to conduct robust SRMAs. By effectively integrating qualitative and quantitative evidence, SRMAs can address complex healthcare questions more thoroughly than traditional reviews. Furthermore, these step-by-step guidelines will help researchers to address the challenges of synthesizing diverse types of evidence, thereby improving the rigor, relevance, and applicability of their findings in healthcare decision-making processes.