Amin Uroosa, Adnan Qurat-Ul-Ain, Ahmad Tauseef
Uroosa Amin, Ziauddin College of Rehabilitation Sciences, Ziauddin University, Khayaban-e-Saadi Road, Boat Basin, Karachi, Pakistan.
Qurat-ul-Ain Adnan, PhD (Scholar) Vice Principal, Assistant Professor, Ziauddin College of Rehabilitation Sciences, Ziauddin University, Khayaban-e-Saadi Road, Boat Basin, Karachi, Pakistan.
Pak J Med Sci. 2024 Sep;40(8):1613-1618. doi: 10.12669/pjms.40.8.9045.
To evaluate the effects of CT to improve HbA1C and ABI among the T2DM-associated PAD population.
A randomized, single-blinded, two-arm trial was conducted at the Department of Rehabilitation Sciences of Dr. Ziauddin Hospital in Karachi between July to September 2023. A total of 80 T2DM-associated PAD patients were included and randomly divided into Experimental Group (n=40) and Control Group (n=40), using the sealed envelope method. Experimental group patients received Concurrent Training (CT), whereas Control Group patients underwent Aerobic Training (AT) for 12 weeks. Both groups received thirty-minute sessions three times a week that was progressed to 60 minutes over 12 weeks. HbA1C and ABI were measured at baseline and after 12 weeks.
Analysis revealed an average age of 46.75±3.59 and the duration of T2DM for developing PAD is 14.82±2.23 on average. Findings revealed that both training groups were significantly effective (p<0.000) at 95% CI in improving glycemic and vascular parameters after 12 weeks. Subsequently, findings showed that the CT group showed more significant improvement than AT group in improving HbA1C for glycemic control (p=0.002, CT: pre: 9.53±1.406, post: 7.81±0.81, AT: pre: 8.74±0.908, post: 8.15±0.83) and ABI for systemic blood flow (p=0.0001, CT: pre: 0.84±0.03, post: 0.94±0.03, AT: pre: 0.82±0.02, post: 0.86±0.02).
CT showed a two-fold improvement in glycemic control and arterial blood flow than AT group, which represents that CT is an effective therapeutic approach for T2DM-associated Fontain's stage IIa PAD rehabilitation.
评估协同训练（CT）对2型糖尿病相关外周动脉疾病（PAD）患者糖化血红蛋白（HbA1C）和踝臂指数（ABI）的影响。
2023年7月至9月，在卡拉奇齐亚丁医院康复科学系进行了一项随机、单盲、双臂试验。共纳入80例2型糖尿病相关PAD患者，采用密封信封法随机分为实验组（n = 40）和对照组（n = 40）。实验组患者接受协同训练（CT），而对照组患者进行有氧训练（AT），为期12周。两组均每周进行三次30分钟的训练，12周内逐渐增加至60分钟。在基线和12周后测量HbA1C和ABI。
分析显示平均年龄为46.75±3.59岁，发生PAD的2型糖尿病平均病程为14.82±2.23年。结果显示，两个训练组在12周后改善血糖和血管参数方面均具有显著效果（95%置信区间，p < 0.000）。随后，结果表明，在改善血糖控制的HbA1C方面，CT组比AT组有更显著的改善（p = 0.002，CT：训练前：9.53±1.406，训练后：7.81±0.81；AT：训练前：8.74±0.908，训练后：8.15±0.83）；在改善全身血流的ABI方面，CT组也比AT组有更显著的改善（p = 0.0001，CT：训练前：0.84±0.03，训练后：0.94±0.03；AT：训练前：0.82±0.02，训练后：0.86±0.02）。
与AT组相比，CT在血糖控制和动脉血流方面有两倍的改善，这表明CT是2型糖尿病相关Fontain IIa期PAD康复的有效治疗方法。
