Yu Siying, Long Linna, Zhang Xiaorui, Qiu Yu, Huang Yabo, Huang Xueying, Li Xia, Xu Rong, Fan Chunmei, Huang He
Department of Histology and Embryology, Xiangya School of Medicine, Central South University, Changsha, China.
Department of gynaecology, Xinjiang Cancer Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China.
Heliyon. 2024 Aug 24;10(17):e36888. doi: 10.1016/j.heliyon.2024.e36888. eCollection 2024 Sep 15.
BET family proteins are important epigenetic and transcriptional regulators involved in the control of tumorigenesis and development and have become important targets for cancer therapy. However, there is no systematic bibliometric analysis in this field. A visual analysis of the research hotspots and trends of BET is helpful to understand the future development direction.
We used CiteSpace, VOSviewer, and Excel to visualize and analyze the trends regarding authors, journals, countries or regions, highly cited papers, and keywords in the field.
The results included a total of 946 publications. There are many more papers on BET proteins published since 2013. The papers are mainly from 44 countries, led by the U.S. and China. A total of 7381 authors were identified, among which Bradner, J.E. had the greatest number of articles and the greatest influence. Cancer Discovery was the journal with the most citations per article. Our analysis identified the most influential papers in the field, including highly cited papers and citation burst references. The most frequent keywords included 'expression', 'c-Myc', 'cancer', 'BRD4', 'BET inhibition', 'resistance', 'differentiation', and 'JQ1', which represent the focus of current and developing research fields.
Research on BET is thriving. Collaboration and exchanges between countries and institutions must be strengthened in the future, and the mechanisms of BET-related pathways, the relationship between BET and various diseases, and the development of new BET inhibitors have become the major focus of current research and the trend of future research.
BET家族蛋白是重要的表观遗传和转录调节因子，参与肿瘤发生和发展的调控，已成为癌症治疗的重要靶点。然而，该领域尚无系统的文献计量分析。对BET的研究热点和趋势进行可视化分析有助于了解未来的发展方向。
我们使用CiteSpace、VOSviewer和Excel对该领域的作者、期刊、国家或地区、高被引论文和关键词的趋势进行可视化和分析。
结果共纳入946篇出版物。2013年以来发表的关于BET蛋白的论文更多。这些论文主要来自44个国家，以美国和中国为首。共识别出7381位作者，其中Bradner, J.E.的文章数量最多且影响力最大。《癌症发现》是每篇文章被引次数最多的期刊。我们的分析确定了该领域最具影响力的论文，包括高被引论文和引用爆发参考文献。最常见的关键词包括“表达”“c-Myc”“癌症”“BRD4”“BET抑制”“耐药性”“分化”和“JQ1”，这些代表了当前和正在发展的研究领域的重点。
对BET的研究正在蓬勃发展。未来必须加强国家和机构之间的合作与交流，BET相关通路的机制、BET与各种疾病的关系以及新型BET抑制剂的开发已成为当前研究的主要重点和未来研究的趋势。
