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Metabolism of tRNAs and rRNAs shape immunoactive signatures in chronic obstructive pulmonary disease and pulmonary infections.

作者信息

Hong Zhenyi, Bofill-De Ros Xavier

机构信息

Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.

出版信息

Mol Ther Nucleic Acids. 2024 Aug 29;35(3):102298. doi: 10.1016/j.omtn.2024.102298. eCollection 2024 Sep 10.

DOI:10.1016/j.omtn.2024.102298
PMID:39281696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11401237/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23e1/11401237/8606d4f71c39/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23e1/11401237/8606d4f71c39/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23e1/11401237/8606d4f71c39/gr1.jpg

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本文引用的文献

1
Immunoactive signatures of circulating tRNA- and rRNA-derived RNAs in chronic obstructive pulmonary disease.慢性阻塞性肺疾病中循环tRNA和rRNA衍生RNA的免疫活性特征
Mol Ther Nucleic Acids. 2024 Jul 19;35(3):102285. doi: 10.1016/j.omtn.2024.102285. eCollection 2024 Sep 10.
2
The tRNA half: A strong endogenous Toll-like receptor 7 ligand with a 5'-terminal universal sequence signature.tRNA 半分子:具有 5'-末端通用序列特征的强内源性 Toll 样受体 7 配体。
Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2319569121. doi: 10.1073/pnas.2319569121. Epub 2024 Apr 29.
3
Transfer RNA halves are found as nicked tRNAs in cells: evidence that nicked tRNAs regulate expression of an RNA repair operon.
转移 RNA 片段在细胞中以缺口 tRNA 的形式存在:缺口 tRNA 调节 RNA 修复操纵子表达的证据。
RNA. 2023 May;29(5):620-629. doi: 10.1261/rna.079575.122. Epub 2023 Feb 13.
4
Nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids.被切割的 tRNA 是细胞和生物体液中 tRNA 半分子的稳定储存库。
Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2216330120. doi: 10.1073/pnas.2216330120. Epub 2023 Jan 18.
5
The roles of extracellular vesicles in the immune system.细胞外囊泡在免疫系统中的作用。
Nat Rev Immunol. 2023 Apr;23(4):236-250. doi: 10.1038/s41577-022-00763-8. Epub 2022 Aug 4.
6
Cellular origins of dsRNA, their recognition and consequences.双链 RNA 的细胞起源、识别及其后果。
Nat Rev Mol Cell Biol. 2022 Apr;23(4):286-301. doi: 10.1038/s41580-021-00430-1. Epub 2021 Nov 23.
7
Infection-induced 5'-half molecules of tRNAHisGUG activate Toll-like receptor 7.感染诱导的 tRNAHisGUG 的 5'-半分子激活 Toll 样受体 7。
PLoS Biol. 2020 Dec 17;18(12):e3000982. doi: 10.1371/journal.pbio.3000982. eCollection 2020 Dec.
8
Angiogenin generates specific stress-induced tRNA halves and is not involved in tRF-3-mediated gene silencing.血管生成素生成特定的应激诱导的 tRNA 片段,不参与 tRF-3 介导的基因沉默。
J Biol Chem. 2019 Nov 8;294(45):16930-16941. doi: 10.1074/jbc.RA119.009272. Epub 2019 Oct 3.
9
Recognition of Endogenous Nucleic Acids by the Innate Immune System.固有免疫系统对内源性核酸的识别。
Immunity. 2016 Apr 19;44(4):739-54. doi: 10.1016/j.immuni.2016.04.002.