Veloso Mônica-Rezende, Soares Mariana-Quirino, Soares Andresa-Borges, Panzarella Francine, Nascimento Monikelly, Junqueira José-Luiz
DDS, Postgraduate Program in Oral Radiology, São Leopoldo Mandic Research Institute, Campinas, SP, Brazil.
Professor, Oral Radiology Division, São Leopoldo Mandic Research Institute, Campinas, SP, Brazil.
J Clin Exp Dent. 2024 Aug 1;16(8):e998-e1003. doi: 10.4317/jced.61827. eCollection 2024 Aug.
Osteosarcomas in the maxillofacial region are rare and present different clinical and epidemiological aspects than those diagnosed in the long bones. This retrospective cross-sectional observational study aimed to report the characteristics of osteosarcomas of the jaws diagnosed in an oral pathology reference laboratory.
Information (gender, location of origin, age, symptoms, lesion evolution time, and clinical appearance) regarding the cases diagnosed as osteosarcomas between 2001 and 2023 were obtained from histopathology reports, exam request forms, and clinical photographs. All radiographs were evaluated on a high-resolution screen by a previously trained radiologist. A 20-year experienced pathologist reviewed the histopathological slides and determined the predominant matrix of the lesions: osteoblastic, chondroblastic, or fibroblastic.
Seventeen out of 33,692 cases diagnosed by the oral pathology laboratory over 22 years were osteosarcomas and 10 were included for analysis. The majority were diagnosed in males (60%) and the overall mean age was 37.8±21.6 years. A swollen, reddish, and ulcerated area was the most common clinical appearance. The mean evolution time of the lesions was 5.2±6.6 months. The majority of osteosarcomas were histologically classified as osteoblastic (80%). The radiographic appearance of the lesions was predominantly mixed (60%), presenting tooth resorption (44.4%) or displacement (33.3%), pericementum thickening (55.5%), mandibular canal erosion (71.4%) and sunray periosteal reaction (80%).
The osteosarcomas of the jaws are predominantly osteoblastic with a swollen, reddish, and ulcerated clinical appearance. Imaging exams reveal mixed lesions with sunray periosteal reaction. Oral Pathology, Radiology, Osteosarcoma, Imaging diagnosis.
颌面部骨肉瘤较为罕见，与长骨诊断的骨肉瘤相比，具有不同的临床和流行病学特征。本回顾性横断面观察研究旨在报告在口腔病理学参考实验室诊断的颌骨骨肉瘤的特征。
从组织病理学报告、检查申请表和临床照片中获取2001年至2023年间诊断为骨肉瘤病例的信息（性别、起源部位、年龄、症状、病变演变时间和临床表现）。所有X光片均由一名先前经过培训的放射科医生在高分辨率屏幕上进行评估。一位有20年经验的病理学家复查了组织病理学切片，并确定病变的主要基质：成骨细胞型、软骨细胞型或纤维母细胞型。
在口腔病理学实验室22年诊断的33692例病例中，有17例为骨肉瘤，其中10例纳入分析。大多数病例为男性（60%），总体平均年龄为37.8±21.6岁。肿胀、发红和溃疡区域是最常见的临床表现。病变的平均演变时间为5.2±6.6个月。大多数骨肉瘤在组织学上被分类为成骨细胞型（80%）。病变的影像学表现主要为混合型（60%），表现为牙齿吸收（44.4%）或移位（33.3%）、牙周膜增厚（55.5%）、下颌管侵蚀（71.4%）和日光射线样骨膜反应（80%）。
颌骨骨肉瘤主要为成骨细胞型，临床表现为肿胀、发红和溃疡。影像学检查显示伴有日光射线样骨膜反应的混合性病变。口腔病理学、放射学、骨肉瘤、影像诊断。
