Rodriguez-Molinero Jesus, Pozo-Kreilinger Jose Juan, Ruiz-Roca Juan Antonio, Lopez-Sanchez Antonio Francisco, Cebrian-Carretero Jose Luis
Department of Nursery and Stomatology, Faculty of Health Sciences, Rey Juan Carlos University, 28922 Alcorcón, Madrid, Spain.
High-Performance Research, Development and Innovation Group in Dental Biomaterials of Rey Juan Carlos University, 28922 Alcorcón, Madrid, Spain.
Clin Pract. 2024 May 23;14(3):965-979. doi: 10.3390/clinpract14030077.
Osteosarcomas of the jaw (OSJs) are rare tumors with distinct characteristics from osteosarcomas affecting other bones. This study aims to analyze the clinical, pathological, and therapeutic characteristics of OSJs.
A retrospective, descriptive cross-sectional study including patients diagnosed with OSJ registered at the "La Paz" University Hospital, Madrid, was performed.
Data of eight patients with a diagnosis of OSJ were obtained during the study period of 22 years (2002-2024). The mean age of the patients was 41 years. The distribution was 1:1 between the maxilla and mandible. Painful inflammation was the most frequent clinical manifestation. Conventional osteoblastic osteosarcoma was the most predominant histological type. Survival rate at 5 years was 50%, which decreased to 25% at 10 years.
OSJs differ from conventional osteosarcomas of long tubular bones. Surgery continues to be the mainstay of treatment. However, more studies are needed through which more standardized protocols can be proposed for adjuvant therapeutic management.
颌骨骨肉瘤（OSJ）是一种罕见肿瘤，与影响其他骨骼的骨肉瘤具有不同特征。本研究旨在分析颌骨骨肉瘤的临床、病理和治疗特征。
进行了一项回顾性描述性横断面研究，纳入了在马德里“拉巴斯”大学医院登记诊断为颌骨骨肉瘤的患者。
在22年（2002 - 2024年）的研究期间，获得了8例诊断为颌骨骨肉瘤患者的数据。患者的平均年龄为41岁。上颌骨和下颌骨的分布比例为1:1。疼痛性炎症是最常见的临床表现。传统成骨性骨肉瘤是最主要的组织学类型。5年生存率为50%，10年生存率降至25%。
颌骨骨肉瘤与长管状骨的传统骨肉瘤不同。手术仍然是主要的治疗方法。然而，需要进行更多研究，以便能够提出更标准化的辅助治疗管理方案。
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