Yang Hanyi, Guo Kai, Ding Peng, Ning Jiayi, Zhang Yimeng, Wang Yuanyong, Wang Zhaoyang, Liu Guanglin, Shao Changjian, Pan Minghong, Ma Zhiqiang, Yan Xiaolong, Han Jing
Department of Ophthalmology, Tangdu Hospital, The Air Force Military Medical University, Xi'an, Shaanxi 710038, China.
Xi'an Medical University, Xi'an, Shaanxi 710086, China.
Genes Dis. 2024 Jan 22;11(6):101216. doi: 10.1016/j.gendis.2024.101216. eCollection 2024 Nov.
Histone deacetylases (HDACs) are proteases that play a key role in chromosome structural modification and gene expression regulation, and the involvement of HDACs in cancer, the nervous system, and the metabolic and immune system has been well reviewed. Our understanding of the function of HDACs in the vascular system has recently progressed, and a significant variety of HDAC inhibitors have been shown to be effective in the treatment of vascular diseases. However, few reviews have focused on the role of HDACs in the vascular system. In this study, the role of HDACs in the regulation of the vascular system mainly involving endothelial cells and vascular smooth muscle cells was discussed based on recent updates, and the role of HDACs in different vascular pathogenesis was summarized as well. Furthermore, the therapeutic effects and prospects of HDAC inhibitors were also addressed in this review.
组蛋白去乙酰化酶（HDACs）是一类蛋白酶，在染色体结构修饰和基因表达调控中起关键作用，HDACs在癌症、神经系统以及代谢和免疫系统中的作用已有充分综述。我们对HDACs在血管系统中功能的认识最近有了进展，并且已显示多种HDAC抑制剂在治疗血管疾病方面有效。然而，很少有综述关注HDACs在血管系统中的作用。在本研究中，基于最近的进展讨论了HDACs在主要涉及内皮细胞和血管平滑肌细胞的血管系统调节中的作用，并总结了HDACs在不同血管发病机制中的作用。此外，本综述还探讨了HDAC抑制剂的治疗效果和前景。
