Fei Yulang, Liu Han, Sun Kai, Zhang Ou
Department of Biomedical Research Center, Medical College, Xijing University, Xi 'an 710123, Shaanxi Province, China.
The First Affiliated Hospital of Nanyang Medical College, Nanyang 473061, Henan Province, China.
ACS Omega. 2024 Aug 26;9(36):37737-37747. doi: 10.1021/acsomega.4c03137. eCollection 2024 Sep 10.
In this paper, triphenylamine served as the structural core and was bonded to aromatic groups having various substituents [-OH, -OMe, or -N(Et)] by a =N-N= chain and then connected with aromatic groups having various substituents [-OH, -OMe, or -N(Et)]. The geometric and electronic properties of these probes were examined. It was found that the presence of electron donors enhanced the selectivity and emission quantum yield (QY). When exposed to Cu, the fluorescence intensity decreased. The optimal probe (T) showed a significant decrease in emission QY from 17.1 to 0.5% and recovered to 16.8% after exposure to CO for 342 s. The sensing mechanism was revealed to be static quenching, forming a nonfluorescent adduct between probe and Cu. After reacting with CO, Cu was reduced to Cu, and the probe emission was recovered. The bioimaging performance of the optimal probe was assessed as well.
在本文中，三苯胺作为结构核心，通过=N-N=链与具有各种取代基[-OH、-OMe或-N(Et)]的芳基相连，然后与具有各种取代基[-OH、-OMe或-N(Et)]的芳基连接。研究了这些探针的几何和电子性质。发现电子供体的存在提高了选择性和发射量子产率（QY）。当暴露于Cu时，荧光强度降低。最佳探针（T）的发射QY从17.1%显著降低至0.5%，在暴露于CO 342秒后恢复至16.8%。传感机制被揭示为静态猝灭，在探针和Cu之间形成非荧光加合物。与CO反应后，Cu被还原为Cu，探针发射恢复。还评估了最佳探针的生物成像性能。
