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A sequential double blind cross-over trial of tocainide hydrochloride in tinnitus.

作者信息

Blayney A W, Phillips M S, Guy A M, Colman B H

出版信息

Clin Otolaryngol Allied Sci. 1985 Apr;10(2):97-101. doi: 10.1111/j.1365-2273.1985.tb01175.x.

DOI:10.1111/j.1365-2273.1985.tb01175.x
PMID:3928215
Abstract

A sequential double blind cross-over trial of tocainide hydrochloride, an oral analogue of lignocaine, is reported. The dosage of tocainide hydrochloride ranged from 200-600 mg daily. Of the 32 patients who completed the trial, 1 had complete relief and 2 had partial relief of their tinnitus whilst taking tocainide. An increased incidence of side-effects in patients taking tocainide was noted, in particular, headache, dizziness, nausea and skin rashes.

摘要

相似文献

1
A sequential double blind cross-over trial of tocainide hydrochloride in tinnitus.
Clin Otolaryngol Allied Sci. 1985 Apr;10(2):97-101. doi: 10.1111/j.1365-2273.1985.tb01175.x.
2
The effect of intra-venous lidocaine and several different doses oral tocainide HCl on tinnitus. A dose-finding study.静脉注射利多卡因和几种不同剂量的口服盐酸妥卡尼对耳鸣的影响。一项剂量探索性研究。
Acta Otolaryngol. 1984 Sep-Oct;98(3-4):231-8. doi: 10.3109/00016488409107559.
3
Treatment of tinnitus with tocainide hydrochloride.盐酸妥卡尼治疗耳鸣
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4
The value of tocainide in the treatment of tinnitus. A double-blind controlled study.
Arch Otorhinolaryngol. 1985;241(3):279-83. doi: 10.1007/BF00453701.
5
Assessment of the value of tocainide hydrochloride in the treatment of tinnitus.盐酸妥卡尼治疗耳鸣的价值评估。
J Laryngol Otol. 1982 Nov;96(11):981-4. doi: 10.1017/s0022215100093397.
6
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Int J Clin Pharmacol Ther Toxicol. 1986 Apr;24(4):207-12.
7
[Tinnitus therapy with lidocaine and tocainide].
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8
Treatment of tinnitus with lidocaine and tocainide.利多卡因和妥卡尼治疗耳鸣
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Tocainide and tinnitus. Clinical effect and site of action.妥卡尼与耳鸣。临床疗效及作用部位。
ORL J Otorhinolaryngol Relat Spec. 1984;46(1):24-33. doi: 10.1159/000275680.

引用本文的文献

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Review of Pharmacotherapy for Tinnitus.耳鸣的药物治疗综述
Healthcare (Basel). 2021 Jun 21;9(6):779. doi: 10.3390/healthcare9060779.
2
Tinnitus: network pathophysiology-network pharmacology.耳鸣：网络病理生理学-网络药理学。
Front Syst Neurosci. 2012 Jan 25;6:1. doi: 10.3389/fnsys.2012.00001. eCollection 2012.
3
PHARMACOLOGICAL TREATMENTS FOR TINNITUS: NEW AND OLD.耳鸣的药物治疗：新旧方法
Drugs Future. 2009;34(5):381-400. doi: 10.1358/dof.2009.034.05.1362442.
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Emerging pharmacotherapy of tinnitus.耳鸣的新兴药物治疗学。
Expert Opin Emerg Drugs. 2009 Dec;14(4):687-702. doi: 10.1517/14728210903206975.