Mirro R, Tamura M, Kawano T
Crit Care Med. 1985 Sep;13(9):724-7. doi: 10.1097/00003246-198509000-00006.
High-frequency oscillation (HFO) appears to be an alternate, less traumatic mode of ventilating surfactant-deficient patients, because conventional (mechanical) pressure-limited ventilation (CMV) compromises cardiac function at high mean airway pressures. We compared systemic cardiac output and its distribution during HFO and CMV in ten adult rabbits rendered surfactant deficient by repeated pulmonary saline lavage. Cardiac output and organ blood flow were measured using the radionucleotide-labeled microsphere technique during ventilation at a mean airway pressure of 15 cm H2O and an inspired oxygen concentration of 100%. Both cardiac output and organ perfusion were similar during both modes of ventilation.
高频振荡（HFO）似乎是一种用于为表面活性物质缺乏的患者通气的替代方式，且创伤较小，因为传统（机械）压力限制通气（CMV）在高平均气道压时会损害心功能。我们比较了10只通过反复肺盐水灌洗导致表面活性物质缺乏的成年兔在高频振荡通气和传统压力限制通气期间的心输出量及其分布。在平均气道压为15 cm H2O、吸入氧浓度为100%的通气过程中，使用放射性核素标记微球技术测量心输出量和器官血流量。两种通气模式下心输出量和器官灌注均相似。
