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撤稿声明:泽布替尼通过抑制ARHI甲基化增强人骨肉瘤细胞凋亡。

RETRACTION: Zebularine Enhances Apoptosis of Human Osteosarcoma Cells by Suppressing Methylation of ARHI.

出版信息

Cancer Sci. 2024 Dec;115(12):4080. doi: 10.1111/cas.16346. Epub 2024 Sep 16.

DOI:10.1111/cas.16346
PMID:39282753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11611752/
Abstract

K. Ye, S. Wang, J. Wang, H. Han, B. Ma and Y. Yang, "Zebularine Enhances Apoptosis of Human Osteosarcoma Cells by Suppressing Methylation of ARHI," Cancer Science 107, no. 12 (2016): 1851-1857, https://doi.org/10.1111/cas.13088. The above article, published online on 29 September 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Masanori Hatakeyama; the Japanese Cancer Association; and John Wiley & Sons Australia, Ltd. The retraction has been agreed following an investigation into concerns raised by a third party, which revealed that the western blots presented in figure 4a and 4d contain duplicated bands. Furthermore, duplications were found between bands within figure 4d itself, some of which appear to have been horizontally flipped. The authors did not respond to the concerns raised and did not provide their original data. The editors consider the results and conclusion reported in this article unreliable.

摘要

叶凯、王爽、王晶、韩浩、马博和杨阳,“泽布勒明通过抑制ARHI甲基化增强人骨肉瘤细胞凋亡”,《癌症科学》107卷,第12期(2016年):1851 - 1857页,https://doi.org/10.1111/cas.13088 。上述文章于2016年9月29日在线发表于威利在线图书馆(wileyonlinelibrary.com),经该期刊主编武田正典、日本癌症协会以及约翰威立父子澳大利亚有限公司协商一致后予以撤回。此次撤回是在对第三方提出的担忧进行调查之后达成的,调查发现图4a和4d中的蛋白质免疫印迹包含重复条带。此外,在图4d本身的条带之间也发现了重复,其中一些似乎是水平翻转的。作者未对提出的担忧做出回应,也未提供原始数据。编辑认为本文报道的数据和结论不可靠。

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