School of Biomedical Sciences, Hunan University, Changsha, Hunan, China.
Methods Mol Biol. 2025;2856:445-453. doi: 10.1007/978-1-0716-4136-1_26.
Cohesin is a protein complex that plays a key role in regulating chromosome structure and gene expression. While next-generation sequencing technologies have provided extensive information on various aspects of cohesin, integrating and exploring the vast datasets associated with cohesin are not straightforward. CohesinDB ( https://cohesindb.iqb.u-tokyo.ac.jp ) offers a web-based interface for browsing, searching, analyzing, visualizing, and downloading comprehensive multiomics cohesin information in human cells. In this protocol, we introduce how to utilize CohesinDB to facilitate research on transcriptional regulation and chromatin organization.
黏连蛋白是一种在调节染色体结构和基因表达方面起关键作用的蛋白质复合物。尽管下一代测序技术为黏连蛋白的各个方面提供了广泛的信息，但整合和探索与黏连蛋白相关的大量数据集并不简单。黏连蛋白数据库（https://cohesindb.iqb.u-tokyo.ac.jp）提供了一个基于网络的界面，用于浏览、搜索、分析、可视化和下载人类细胞中全面的多组学黏连蛋白信息。在本方案中，我们介绍如何利用黏连蛋白数据库来促进转录调控和染色质组织的研究。
