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Polychlorinated biphenyls (PCBs) as initiating agents in hepatocellular carcinoma.多氯联苯作为肝细胞癌的起始剂。
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本文引用的文献

1
Adsorption of polychlorinated biphenyls (PCB) on glass surfaces.
Dan Tidsskr Farm. 1971;45(7):259-61.
2
Mutability of different genetic loci in mammalian cells by metabolically activated carcinogenic polycyclic hydrocarbons.代谢活化的致癌多环烃对哺乳动物细胞中不同基因位点的可突变性
Proc Natl Acad Sci U S A. 1976 Jan;73(1):188-92. doi: 10.1073/pnas.73.1.188.

多氯联苯及其热合成衍生物在细胞介导试验中的致突变性。

Mutagenicity of PCBs and their pyrosynthetic derivatives in cell-mediated assay.

作者信息

Hattula M L

出版信息

Environ Health Perspect. 1985 May;60:255-7. doi: 10.1289/ehp.8560255.

DOI:10.1289/ehp.8560255
PMID:3928351
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1568588/
Abstract

The mutagenicity of PCBs, Aroclor 1242 and Clophen A60 was studied in a mammalian cell assay using V79 Chinese hamster cells as target cells. The method was used as a direct assay without metabolizing cells and as a cell-mediated assay with 5000 R-irradiated rat fibroblasts as metabolizing cells. A wipe soot sample of a PCB fire was studied in the same assay, and the results showed no mutagenicity of the pure PCBs. However, the wipe sample showed weak mutagenic activity which disappeared when metabolizing cells were used. The chemical analysis of the wipe sample showed tri-, tetra- and pentachlorodibenzofurans in addition to PCBs.

摘要

利用V79中国仓鼠细胞作为靶细胞，在哺乳动物细胞试验中研究了多氯联苯、Aroclor 1242和Clophen A60的致突变性。该方法既用作不进行细胞代谢的直接试验，也用作以5000伦琴照射的大鼠成纤维细胞作为代谢细胞的细胞介导试验。在同一试验中研究了多氯联苯火灾的擦拭烟尘样品，结果表明纯多氯联苯无致突变性。然而，擦拭样品显示出微弱的致突变活性，当使用代谢细胞时该活性消失。擦拭样品的化学分析表明，除多氯联苯外，还含有三氯、四氯和五氯二苯并呋喃。