Fu Zhengjiang, Zeng Junhua, Xiong Cheng, Guo Shengmei, Cai Hu
School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, China, 330031.
Chemistry. 2024 Dec 10;30(69):e202403077. doi: 10.1002/chem.202403077. Epub 2024 Nov 3.
After systematic realization of decarboxylative functionalization of carboxylic acids under heating conditions in our group, we herein reported an electrochemical method for Ni-catalyzed decarboxylative oxygenation of arylacetic acids under open air conditions. The protocol provided corresponding carbonyls including aldehydes and ketones in moderate to satisfactory yields with good functional group tolerance, furthermore, the practicability and advantage of the method was highlighted through Ni-catalyzed oxidative decarboxylation of carboxylic acid-containing drugs and preformation of scalable transformation. Mechanistic studies demonstrated that the possible involvement of free radical intermediate in the conversion.
在我们小组系统实现了羧酸在加热条件下的脱羧官能化之后，我们在此报道了一种在开放空气条件下镍催化芳基乙酸脱羧氧化的电化学方法。该方法以中等至良好的产率提供了相应的羰基化合物，包括醛和酮，且具有良好的官能团耐受性。此外，通过镍催化含羧酸药物的氧化脱羧以及可扩展转化的预形成，突出了该方法的实用性和优势。机理研究表明，自由基中间体可能参与了该转化过程。
